国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
20期
2760-2761,2764
,共3页
手足口病%心肌酶谱%高敏肌钙蛋白%心肌损伤
手足口病%心肌酶譜%高敏肌鈣蛋白%心肌損傷
수족구병%심기매보%고민기개단백%심기손상
hand-foot-mouth disease%myocardial enzymes%troponin%myocardial injury
目的：研究心肌酶谱、高敏肌钙蛋白T（hs-cTnl）在小儿手足口病（HFMD）并发心肌损伤诊断中的临床应用价值。方法143例临床确诊的手足口患儿设为 HFMD 组，并根据心电图检查结果分为心电图正常组（59例）、心电图异常组（84例），选择同期健康体检婴幼儿67例为对照组，比较各组心肌酶谱、cTnT-hs 的变化情况，并研究心电图异常组急性期及恢复期心肌酶谱、cTnT-hs 的变化情况。结果HFMD 心电图异常组心肌酶谱、cTnT-hs 血清浓度及异常率与 HFMD 心电图正常组及对照组比较差异有统计学意义（P ＜0．05），HFMD 心电图正常组与对照组比较差异无统计学意义（P ＞0．05）；HFMD 心电图异常组急性期与恢复期血清浓度 CK、CK-MB、cTnT-hs 差异均有统计学意义（P ＜0．05），AST、LDH 和α-羟基丁酸脱氢酶（α-HBDH）比较差异无统计学意义（P ＞0．05）。结论心肌损伤为 HFMD 患儿较为严重的并发症，临床应以预防为主，对患儿进行心肌酶谱、cT-nT-hs 的监测有重要的临床意义。
目的：研究心肌酶譜、高敏肌鈣蛋白T（hs-cTnl）在小兒手足口病（HFMD）併髮心肌損傷診斷中的臨床應用價值。方法143例臨床確診的手足口患兒設為 HFMD 組，併根據心電圖檢查結果分為心電圖正常組（59例）、心電圖異常組（84例），選擇同期健康體檢嬰幼兒67例為對照組，比較各組心肌酶譜、cTnT-hs 的變化情況，併研究心電圖異常組急性期及恢複期心肌酶譜、cTnT-hs 的變化情況。結果HFMD 心電圖異常組心肌酶譜、cTnT-hs 血清濃度及異常率與 HFMD 心電圖正常組及對照組比較差異有統計學意義（P ＜0．05），HFMD 心電圖正常組與對照組比較差異無統計學意義（P ＞0．05）；HFMD 心電圖異常組急性期與恢複期血清濃度 CK、CK-MB、cTnT-hs 差異均有統計學意義（P ＜0．05），AST、LDH 和α-羥基丁痠脫氫酶（α-HBDH）比較差異無統計學意義（P ＞0．05）。結論心肌損傷為 HFMD 患兒較為嚴重的併髮癥，臨床應以預防為主，對患兒進行心肌酶譜、cT-nT-hs 的鑑測有重要的臨床意義。
목적：연구심기매보、고민기개단백T（hs-cTnl）재소인수족구병（HFMD）병발심기손상진단중적림상응용개치。방법143례림상학진적수족구환인설위 HFMD 조，병근거심전도검사결과분위심전도정상조（59례）、심전도이상조（84례），선택동기건강체검영유인67례위대조조，비교각조심기매보、cTnT-hs 적변화정황，병연구심전도이상조급성기급회복기심기매보、cTnT-hs 적변화정황。결과HFMD 심전도이상조심기매보、cTnT-hs 혈청농도급이상솔여 HFMD 심전도정상조급대조조비교차이유통계학의의（P ＜0．05），HFMD 심전도정상조여대조조비교차이무통계학의의（P ＞0．05）；HFMD 심전도이상조급성기여회복기혈청농도 CK、CK-MB、cTnT-hs 차이균유통계학의의（P ＜0．05），AST、LDH 화α-간기정산탈경매（α-HBDH）비교차이무통계학의의（P ＞0．05）。결론심기손상위 HFMD 환인교위엄중적병발증，림상응이예방위주，대환인진행심기매보、cT-nT-hs 적감측유중요적림상의의。
Objective To study the clinical application value of myocardial enzymes and troponin in children hand-foot-mouth disease complicating myocardial injury.Methods 143 cases of clinically diagnosed children hand-foot-mouth disease were set as the HFMD group,and divided into the normal group (59 cases)and abnormal electrocardiogram group (84 cases)according to the ECG examination results.Contemporaneous 67 healthy infants and young children with physical examination were selected as the control group.The changes of myocardial enzymes and troponin were compared among various groups.The change situation of myocardial enzymes and troponin during acute and convalescent stages in abnormal ECG group were studied.Results The myocardial en-zymes,serum troponin concentration and the abnormal rate had statistical differences between the HFMD abnormal ECG group with the HFMD normal EKG group and the control group (P <0.05),which had no statistical difference between in the HFMD normal ECG group and the control group (P >0.05);the serum CK,CK-MB cTnT-hs levels had statistical differences between the acute stage and the convalescent stage in the HFMD abnormal EKG group(P <0.05),AST,LDH and α-HBDH had no statistical differ-ences (P >0.05).Conclusion Myocardial injury is more serious complication in children patients with HFMD,clinic should take prevention first,conducting the monitoring of myocardial enzymes and troponin has important clinical significance.
