CAJ | 학술논문

目的：测定替加环素对碳青霉烯类耐药鲍曼醋酸钙复合不动杆菌的体外抗菌活性。方法收集2013年12月至2014年2月本院分离的碳青霉烯类耐药鲍曼醋酸钙复合不动杆菌，采用 MTS 法检测替加环素 MIC 值，折点采用美国食品药物管理局（FDA）公布的判定标准。结果61株碳青霉烯类耐药鲍曼醋酸钙复合不动杆菌对临床常用抗菌药物具有极高的耐药率，替加环素的灵敏度为80．3％，中介率为19．7％，无耐药菌株。MIC90为3μg/mL，而 MIC50为2μg/mL。结论替加环素对于本院分离的碳青霉烯类耐药鲍曼醋酸钙复合不动杆菌有较好的体外抗菌活性。
목적：측정체가배소대탄청매희류내약포만작산개복합불동간균적체외항균활성。방법수집2013년12월지2014년2월본원분리적탄청매희류내약포만작산개복합불동간균，채용 MTS 법검측체가배소 MIC 치，절점채용미국식품약물관리국（FDA）공포적판정표준。결과61주탄청매희류내약포만작산개복합불동간균대림상상용항균약물구유겁고적내약솔，체가배소적령민도위80．3％，중개솔위19．7％，무내약균주。MIC90위3μg/mL，이 MIC50위2μg/mL。결론체가배소대우본원분리적탄청매희류내약포만작산개복합불동간균유교호적체외항균활성。
Objective To measure the in vitro antibacterial activity of tigecycline against carbapenems-resistant Acinetobacter calcoacetcus-Acinetobacter baumannii complex.Methods The isolated strains of carbapenems-resistant Acinetobacter calcoacetcus-Acinetobacter baumannii complex were collected in our hospital from December 2013 to February 2014.The MIC test strip was a-dopted to measure the MIC value of tigecycline.The break point adopted the judgment criteria published by FDA.Results All 61 strains of carbapenems-resistant Acinetobacter calcoacetcus-Acinetobacter baumannii complex had extremely high drug resistant rate to the commonly used antimicrobial agents.The sensitive rate of tigecycline was 80.3%,intermediation was 19.7% and no re-sistant strain was found in this study.MIC50 and MIC90 were 2 μg/mL and 3 μg/mL respectively.Conclusion Tigecycline has bet-ter in vitro antibacterial activity to the carbapenems-resistant Acinetobacter calcoacetcus-Acinetobacter baumannii complex isolated in our hospital.