CAJ | 학술논문

目的：探讨血清神经胶质纤维酸性蛋白（GFAP ）、髓鞘碱性蛋白（MBP ）联合检测在早期脑挫裂伤患者诊断中的价值。方法采用酶联免疫吸附实验（ELISA）法检测血清 GFAP、MBP 浓度，多组间比较采用单因素方差分析，两两比较采用 q 检验分析脑挫裂伤患者与健康人群间的差异。结果血清 GFAP、MBP 浓度，轻、重型颅脑损伤组与健康对照组3组间统计学分析差异有统计学意义（P ＜0．05）；对照组与轻型颅脑损伤组比较差异有统计学意义（P ＜0．05）；轻、重型颅脑损伤组比较差异有统计学意义（P ＜0．05）；对照组与重型颅脑损伤组比较差异有统计学意义（P ＜0．05）。脑挫裂伤患者早期血清 GFAP、MBP 浓度明显高于对照组，且损伤越重升高越明显。结论血清 GFAP、MBP 水平联合检测可以作为早期脑挫裂伤诊断及评估损伤程度的辅助指标。
목적：탐토혈청신경효질섬유산성단백（GFAP ）、수초감성단백（MBP ）연합검측재조기뇌좌렬상환자진단중적개치。방법채용매련면역흡부실험（ELISA）법검측혈청 GFAP、MBP 농도，다조간비교채용단인소방차분석，량량비교채용 q 검험분석뇌좌렬상환자여건강인군간적차이。결과혈청 GFAP、MBP 농도，경、중형로뇌손상조여건강대조조3조간통계학분석차이유통계학의의（P ＜0．05）；대조조여경형로뇌손상조비교차이유통계학의의（P ＜0．05）；경、중형로뇌손상조비교차이유통계학의의（P ＜0．05）；대조조여중형로뇌손상조비교차이유통계학의의（P ＜0．05）。뇌좌렬상환자조기혈청 GFAP、MBP 농도명현고우대조조，차손상월중승고월명현。결론혈청 GFAP、MBP 수평연합검측가이작위조기뇌좌렬상진단급평고손상정도적보조지표。
Objective To investigate the diagnostic value of the combined detection of serum glial fibrillary acidic protein (GFAP)and myelin basic protein (MBP)in the patients with early brain contusion and laceration.Methods ELISA was adopted to detect serum GFAP and MBP.The one-way ANOVA analysis was adopted to conduct the comparison among groups and the q test was adopted to conduct the pairwise comparison for analyzing the differences between the brain contusion and laceration patients with the healthy population.Results The serum GFAP and MBP levels had statistically significant differences among the mild craniocerebral injury group,severe craniocerebral injury group and the healthy control (P <0.05);which had statistically signifi-cant differences between the control group and the mild craniocerebral injury group(P <0.05);which had statistically significant differences between the mild craniocerebral injury group and the severe craniocerebral group (P <0.05 );which had statistically significant differences between the control group and the severe craniocerebral injury group (P <0.05).The serum GFAP and MBP levels in the early stage of brain contusion and laceration were significantly higher than those in the control group,moreover,the more severe the injury,the more obvious the increase of serum GFAP and MBP.Conclusion The combined detection of serum GFAP and MBP can be regarded as the auxiliary indexes for the early diagnosis of early brain contusion and laceration and the eval-uation of the injury degree.