CAJ | 학술논문

目的：探讨联合测定降钙素原（PCT）和超敏C 反应蛋白（hs-CRP）对新生儿败血症早期诊断和病情评估的应用价值。方法收集2011年11月至2013年5月期间收治于鄂尔多斯市中心医院的新生儿败血症患儿48例，记录患儿的 PCT、hs-CRP 及血培养等资料，并与同期48例非败血症新生儿的血清 PCT 和 hs-CRP 检测结果作对比分析。结果败血症患儿血清PCT（93．75％）、hs-CRP（10．42％）明显高于非败血症患儿血清 PCT（79．17％）、hs-CRP（50％），两组间阳性率比较差异有统计学意义（P ＜0．05）。结论PCT 和 hs-CRP 在新生儿败血症早期有显著改变，血清 PCT 和 hs-CRP 的联合测定可以作为诊断新生儿败血症的早期诊断指标，且 PCT 的灵敏度和特异度均较 hs-CRP 高，两者的联合检测能为临床提供准确、快速的诊断依据。
목적：탐토연합측정강개소원（PCT）화초민C 반응단백（hs-CRP）대신생인패혈증조기진단화병정평고적응용개치。방법수집2011년11월지2013년5월기간수치우악이다사시중심의원적신생인패혈증환인48례，기록환인적 PCT、hs-CRP 급혈배양등자료，병여동기48례비패혈증신생인적혈청 PCT 화 hs-CRP 검측결과작대비분석。결과패혈증환인혈청PCT（93．75％）、hs-CRP（10．42％）명현고우비패혈증환인혈청 PCT（79．17％）、hs-CRP（50％），량조간양성솔비교차이유통계학의의（P ＜0．05）。결론PCT 화 hs-CRP 재신생인패혈증조기유현저개변，혈청 PCT 화 hs-CRP 적연합측정가이작위진단신생인패혈증적조기진단지표，차 PCT 적령민도화특이도균교 hs-CRP 고，량자적연합검측능위림상제공준학、쾌속적진단의거。
Objective Too investigate the application value of procalcitonin(PCT)and high sensitivity C-reactive protein(hs-CRP)in early diagnosis of neonatal septicemia and disease condition assessment.Methods 48 patients with neonatal septicemia treated in the hospital from November 2011 to May 2013 were collected.The data of PCT,hs-CRP and blood culture were recorded and performed the comparative analysis with the serum PCT,hs-CRP detection results in contemporaneous 48 neonates without septicemia.Results The serum PCT and hs-CRP was 93.75% and 10.42% in the neonates with septicemia,which were signifi-cantly higher than 79.17% and 50% in the neonates without septicemia(P <0.05),the positive rate had statistical difference be-tween the two groups.Conclusion PCT and hs-CRP have remarkable change in the early stage of neonatal sepsis,the combination detection of serum PCT and hs-CRP can be used as the indicators for early diagnosis of neonatal sepsis,moreover the sensitivity and specificity of PCT for diagnosing neonatal septicemia are higher the those of hs-CRP,their combined detection can provide fast and accurate diagnostic basis for clinic.