CAJ | 학술논문

目的：分析新生儿ABO血型正反定型的符合情况及与异型血交叉配血的试验结果，探讨交叉配血试验在婴幼儿输血时的局限性及保证新生儿安全输血的有效措施。方法对1095例新生儿血液标本用微柱凝胶卡进行 ABO 血型鉴定，并与异型血做交叉配血试验。结果1095例新生儿标本中，弱 A、弱 B 抗原检出率分别为3．99％、17．93％，以弱 B 抗原为主；血型抗体阴性率抗-A 为53．72％，抗-B 为60．70％；与异型血做交叉配血时，主侧未出现预期凝集者占52．87％，弱凝集占33．27％，次侧弱凝集占9．49％。结论新生儿 ABO 抗原抗体成熟度及正反定型符合率均不及成人，依据交叉配血试验结果进行输血有一定局限性，应高度重视新生儿 ABO 血型的正确性，明确新生儿个体输血策略，以免给新生儿误输 ABO 异型血造成溶血性输血反应，保证其输血安全。
목적：분석신생인ABO혈형정반정형적부합정황급여이형혈교차배혈적시험결과，탐토교차배혈시험재영유인수혈시적국한성급보증신생인안전수혈적유효조시。방법대1095례신생인혈액표본용미주응효잡진행 ABO 혈형감정，병여이형혈주교차배혈시험。결과1095례신생인표본중，약 A、약 B 항원검출솔분별위3．99％、17．93％，이약 B 항원위주；혈형항체음성솔항-A 위53．72％，항-B 위60．70％；여이형혈주교차배혈시，주측미출현예기응집자점52．87％，약응집점33．27％，차측약응집점9．49％。결론신생인 ABO 항원항체성숙도급정반정형부합솔균불급성인，의거교차배혈시험결과진행수혈유일정국한성，응고도중시신생인 ABO 혈형적정학성，명학신생인개체수혈책략，이면급신생인오수 ABO 이형혈조성용혈성수혈반응，보증기수혈안전。
Objective To analyze the coincidence situation of the results of neonatal ABO blood group reciprocal stereotypy with crossmatching test of allotype blood and to investigating the limitations of cross-matching test in infant blood transfusion and effec-tive measures for ensuring the neonatal safe blood transfusion.Methods The micro-column gel test was adopted to identify the ABO blood group and conduct the crosshatching test of allotype blood in 1 095 cases of neonatal blood samples.Results Among the 1 095 samples,the detected rates of weak A and weak B antigen were 3.99% and 17.93% respectively,and the weak B antigen was predominant.The negative rates of anti-A and anti-B antibody were 53.72% and 60.70% respectively;in the cross-matching test with allotype blood,the main side without appearing agglutination accounted for 52.87% and weak agglutination accounted for 33.27%,and the secondary side appearing weak agglutination accounted for 9.49%.Conclusion The maturity of antibody and an-tigen and the coincidence rates of group typing and reciprocal stereotypy in the newborns are less than those in the adults;so blood transfusion according to the cross-matching test results has certain limitation;high attention should be paid to the accuracy of neo-natal ABO blood type,the individual blood transfusion strategy in the newborn should be determined in order to avoid hemolytic blood transfusion reaction caused by ABO allotype blood transfusion and ensure the blood transfusion safety in newborns.