国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
20期
2749-2750,2753
,共3页
过敏原%特异性 IgE%过敏性哮喘%敏性鼻炎
過敏原%特異性 IgE%過敏性哮喘%敏性鼻炎
과민원%특이성 IgE%과민성효천%민성비염
allergen%specific IgE%allergic asthma%allergic rhinitis
目的：探讨过敏性哮喘和鼻炎患儿的特异性免疫治疗的临床应用。方法采用体外特异性过敏原检测系统对儿童医院门诊患儿进行血清过敏原特异性 lgE（SlgE）抗体和总 lgE 进行检测，对尘螨过敏患儿进行分组治疗，免疫治疗组采用粉尘螨滴剂舌下脱敏治疗，对照组按普通药物抗过敏治疗，治疗6个月、12个月给予临床控制指标评分，同时观察患儿血清中 SIgE 的改变。结果218例过敏患儿吸入性过敏114例（52．4％），食入性过敏101例（46．3％）。98例尘螨过敏患儿占总过敏者和吸入性过敏者的44．95％和85．96％。免疫治疗组与对照组比较差异有统计学意义（P ＜0．05）；脱敏治疗患儿 SIgE 阳性率有所下降，但差异无统计学意义（P ＞0．05）。结论218例过敏患儿的特异性过敏原检测中尘螨过敏者最多；舌下特异性免疫治疗过敏性哮喘和鼻炎效果显著。
目的：探討過敏性哮喘和鼻炎患兒的特異性免疫治療的臨床應用。方法採用體外特異性過敏原檢測繫統對兒童醫院門診患兒進行血清過敏原特異性 lgE（SlgE）抗體和總 lgE 進行檢測，對塵螨過敏患兒進行分組治療，免疫治療組採用粉塵螨滴劑舌下脫敏治療，對照組按普通藥物抗過敏治療，治療6箇月、12箇月給予臨床控製指標評分，同時觀察患兒血清中 SIgE 的改變。結果218例過敏患兒吸入性過敏114例（52．4％），食入性過敏101例（46．3％）。98例塵螨過敏患兒佔總過敏者和吸入性過敏者的44．95％和85．96％。免疫治療組與對照組比較差異有統計學意義（P ＜0．05）；脫敏治療患兒 SIgE 暘性率有所下降，但差異無統計學意義（P ＞0．05）。結論218例過敏患兒的特異性過敏原檢測中塵螨過敏者最多；舌下特異性免疫治療過敏性哮喘和鼻炎效果顯著。
목적：탐토과민성효천화비염환인적특이성면역치료적림상응용。방법채용체외특이성과민원검측계통대인동의원문진환인진행혈청과민원특이성 lgE（SlgE）항체화총 lgE 진행검측，대진만과민환인진행분조치료，면역치료조채용분진만적제설하탈민치료，대조조안보통약물항과민치료，치료6개월、12개월급여림상공제지표평분，동시관찰환인혈청중 SIgE 적개변。결과218례과민환인흡입성과민114례（52．4％），식입성과민101례（46．3％）。98례진만과민환인점총과민자화흡입성과민자적44．95％화85．96％。면역치료조여대조조비교차이유통계학의의（P ＜0．05）；탈민치료환인 SIgE 양성솔유소하강，단차이무통계학의의（P ＞0．05）。결론218례과민환인적특이성과민원검측중진만과민자최다；설하특이성면역치료과민성효천화비염효과현저。
Objective To investigate the clinical application of specific allergen immunotherapy (AIT)for the children with al-lergic asthma and rhinitis.Methods The in vitro specific allergen test system was adopted to detect allergen specific IgE and total IgE in children outpatients of the Children's Hospital.The children patients with dust mite allergy were divided into groups for con-ducting therapy.The immunotherapy group adopted the Dermatophagoides farinae drops for hypoglossis desensitization therapy, while the control group was performed the anti-allergic therapy by the common drugs.The clinical control indicator scores were per-formed after 6-months and 12-month therapy and at the same time the change of serum specific LgE was observed.Results Among 218 cases of allergy,114 cases(52.4%)were inhalation allergy and 101 cases (46.3%)were food allergy.98 cases of dust mite al-lergy accounted for 44.95% of the total allergy and 85.96% of the inhalation allergy.The difference in the curative effects between the AIT group and the control group had statistical significance(P <0.01).Conclusion Among 218 children cases of allergy,the dust mite allergy was maximum in the specific allergen detection;the hypoglossis specific immunotherapy has significant curative effect for the children with allergic asthma and rhinitis.
