CAJ | 학술논문

目的：探讨慢性肾脏病（CKD）患者不同时期血清铁蛋白（SF）和甲状旁腺素（PTH）的变化特点与血β2-微球蛋白（β2-MG）的相关性。方法测定不同肾功能时期 SF、PTH 和β2-MG 水平，分别与对照组比较，并将各期 SF、PTH 和β2-MG 水平进行相关性分析。结果代偿组患者 SF、PTH 和β2-MG 水平与对照组比较差异无统计学意义（P ＞0．05），而失代偿组、肾功能衰竭组和尿毒症组与对照组比较差异有统计学意义（P ＜0．05）。相关分析显示，145例患者 PTH 与β2-MG 呈正相关（r＝0．92，P ＜0．05），SF 与β2-MG 亦呈正相关（r＝0．92，P ＜0．05）。结论检测血清 PTH、SF 及β2-MG 水平对了解慢性肾脏病的病情发展和预后判断均有重要的临床价值。
목적：탐토만성신장병（CKD）환자불동시기혈청철단백（SF）화갑상방선소（PTH）적변화특점여혈β2-미구단백（β2-MG）적상관성。방법측정불동신공능시기 SF、PTH 화β2-MG 수평，분별여대조조비교，병장각기 SF、PTH 화β2-MG 수평진행상관성분석。결과대상조환자 SF、PTH 화β2-MG 수평여대조조비교차이무통계학의의（P ＞0．05），이실대상조、신공능쇠갈조화뇨독증조여대조조비교차이유통계학의의（P ＜0．05）。상관분석현시，145례환자 PTH 여β2-MG 정정상관（r＝0．92，P ＜0．05），SF 여β2-MG 역정정상관（r＝0．92，P ＜0．05）。결론검측혈청 PTH、SF 급β2-MG 수평대료해만성신장병적병정발전화예후판단균유중요적림상개치。
Objective To investigate the change characteristics of serum ferritin(SF)and parathormone (PTH)levels in differ-ent stages of chronic kidney disease(CKD)and their correlation with serum beta 2-microglobulin(β2-MG).Methods The levels of serum PTH,SF andβ2-MG in different stages of CKD were detected and the detection results were compared with those in the con-trol group.The correlation between serum SF and PTH withβ2-MG in each stage of CKD was analyzed.Results The level of ser-um PTH,SF andβ2-MG in the compensation group had no statistical difference compared with the control group (P >0.05),while which had statistical differences among the decompensation group,renal failure group and uremia group (P <0.05)The correlation analysis showed that serum PTH was positively correlated with serumβ2-MG in 145 cases(r=0.92,P <0.05),and the serum SF level was also positively correlated with serumβ2-MG level(r=0.92,P <0.05).Conclusion Detecting serum PTH,SF andβ2-MG levels possesses the important clinical significance for understanding CKD condition and prognosis.