CAJ | 학술논문

目的：探讨原发性高血压与血清同型半胱氨酸（HCY）、尾加压素Ⅱ（UⅡ）、血管紧张素转化酶（ACE）及B型钠尿肽前体 N 端（NT-proBNP）之间的相关性。方法通过临床病例的收集，采用酶联免疫吸附法（ELISA）测定 UⅡ，同时测定血清中HCY、ACE 及 NT-proBNP 水平，并对高血压患者与健康人群之间4项检测指标进行分析比较。结果血清 HCY、UⅡ、ACE 及NT-proBNP 水平与对照组相比，原发性高血压（EH）组患者血清中 HCY、UⅡ、ACE 及 NT-proBNP 水平均有显著性升高。EH组患者血清中 HCY、UⅡ、ACE 及 NT-proBNP 在 ROC 曲线中的曲线下面积（AUC）分别为0．93、0．765、0．792、0．972，均具有临床诊断意义。结论原发性高血压患者血清中 HCY、UⅡ、ACE 及 BNP 高表达，与健康人群之间有显著性差异，对于原发性高血压具有诊断价值。
목적：탐토원발성고혈압여혈청동형반광안산（HCY）、미가압소Ⅱ（UⅡ）、혈관긴장소전화매（ACE）급B형납뇨태전체 N 단（NT-proBNP）지간적상관성。방법통과림상병례적수집，채용매련면역흡부법（ELISA）측정 UⅡ，동시측정혈청중HCY、ACE 급 NT-proBNP 수평，병대고혈압환자여건강인군지간4항검측지표진행분석비교。결과혈청 HCY、UⅡ、ACE 급NT-proBNP 수평여대조조상비，원발성고혈압（EH）조환자혈청중 HCY、UⅡ、ACE 급 NT-proBNP 수평균유현저성승고。EH조환자혈청중 HCY、UⅡ、ACE 급 NT-proBNP 재 ROC 곡선중적곡선하면적（AUC）분별위0．93、0．765、0．792、0．972，균구유림상진단의의。결론원발성고혈압환자혈청중 HCY、UⅡ、ACE 급 BNP 고표체，여건강인군지간유현저성차이，대우원발성고혈압구유진단개치。
Objective To study the relationship between essential hypertension(EH)with serum homocysteine(HCY),uroten-sinⅡ(UⅡ),angiotensin converting enzyme(ACE)and N-terminal pro-brain natriuretic peptide(NT-proBNP).Methods By collec-ting the clinical cases,UⅡwas determined by ELISA and HCY,ACE and NT-proBNP were simultaneously detected by ELISA.The detection results were analyzed and compared between the patients with essential hypertension(EH group)and the healthy con-trols.Results The levels of serum HCY,UⅡ,ACE and NT-proBNP in the EH group were significantly increased compared with the healthy control group;the area under curve (AUC)of serum HCY,UⅡ,ACE and NT-proBNP in the ROC curve in the EH group were 0.93,0.765,0.792 and 0.972 respectively,which showed clinical diagnostic significance.Conclusion The levels of HCY,UⅡ,ACE and NT-proBNP are highly expressed in EH and have significant differences compared with the healthy popula-tion,which has the diagnostic value to EH.