国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
20期
2739-2740,2743
,共3页
乙型肝炎病毒%乙型肝炎病毒血清学标志物%乙型肝炎病毒脱氧核糖核酸
乙型肝炎病毒%乙型肝炎病毒血清學標誌物%乙型肝炎病毒脫氧覈糖覈痠
을형간염병독%을형간염병독혈청학표지물%을형간염병독탈양핵당핵산
hepatitis B virus%HBV serological marker%HBV DNA
目的:探讨兰州地区慢性乙型肝炎病毒(HBV)感染者血清乙型肝炎病毒脱氧核糖核酸(HBV DNA)载量与乙型肝炎病毒血清学标志物(HBV-M)HBsAg、HBeAg、HBeAb、HBcAb 的相关性。方法724例 HBV 感染者分别利用实时荧光定量PCR 法检测 HBV DNA 载量,运用双抗体夹心化学发光免疫分析法检测血清 HBsAg、HBeAg、HBeAb、HBcAb 水平。结果兰州地区慢性 HBV 感染者 HBsAg 水平与 HBV DNA 载量呈正相关关系(r=0.342,P <0.05),HBeAg 水平与 HBV DNA 载量呈正相关关系(r=0.463,P <0.05),HBeAb 水平与 HBV DNA 载量之间呈负相关关系(r =-0.227,P =0.001),HBcAb 水平与HBV DNA 载量变化无相关性(r=-0.062,P =0.366)。结论兰州地区慢性 HBV 感染者 HBV DNA 载量和 HBsAg、HBeAg均有明显的正相关关系,提示临床上应把 HBsAg、HBeAg 与 HBV DNA 结合起来观察,能更准确判断患者的传染性程度。
目的:探討蘭州地區慢性乙型肝炎病毒(HBV)感染者血清乙型肝炎病毒脫氧覈糖覈痠(HBV DNA)載量與乙型肝炎病毒血清學標誌物(HBV-M)HBsAg、HBeAg、HBeAb、HBcAb 的相關性。方法724例 HBV 感染者分彆利用實時熒光定量PCR 法檢測 HBV DNA 載量,運用雙抗體夾心化學髮光免疫分析法檢測血清 HBsAg、HBeAg、HBeAb、HBcAb 水平。結果蘭州地區慢性 HBV 感染者 HBsAg 水平與 HBV DNA 載量呈正相關關繫(r=0.342,P <0.05),HBeAg 水平與 HBV DNA 載量呈正相關關繫(r=0.463,P <0.05),HBeAb 水平與 HBV DNA 載量之間呈負相關關繫(r =-0.227,P =0.001),HBcAb 水平與HBV DNA 載量變化無相關性(r=-0.062,P =0.366)。結論蘭州地區慢性 HBV 感染者 HBV DNA 載量和 HBsAg、HBeAg均有明顯的正相關關繫,提示臨床上應把 HBsAg、HBeAg 與 HBV DNA 結閤起來觀察,能更準確判斷患者的傳染性程度。
목적:탐토란주지구만성을형간염병독(HBV)감염자혈청을형간염병독탈양핵당핵산(HBV DNA)재량여을형간염병독혈청학표지물(HBV-M)HBsAg、HBeAg、HBeAb、HBcAb 적상관성。방법724례 HBV 감염자분별이용실시형광정량PCR 법검측 HBV DNA 재량,운용쌍항체협심화학발광면역분석법검측혈청 HBsAg、HBeAg、HBeAb、HBcAb 수평。결과란주지구만성 HBV 감염자 HBsAg 수평여 HBV DNA 재량정정상관관계(r=0.342,P <0.05),HBeAg 수평여 HBV DNA 재량정정상관관계(r=0.463,P <0.05),HBeAb 수평여 HBV DNA 재량지간정부상관관계(r =-0.227,P =0.001),HBcAb 수평여HBV DNA 재량변화무상관성(r=-0.062,P =0.366)。결론란주지구만성 HBV 감염자 HBV DNA 재량화 HBsAg、HBeAg균유명현적정상관관계,제시림상상응파 HBsAg、HBeAg 여 HBV DNA 결합기래관찰,능경준학판단환자적전염성정도。
Objective To investigate the relationship between HBV DNA load with the serological markers(HB-M)HBsAg, HBeAg,HBeAb,HBcAb in the persons infected by chronic hepatitis B virus (HBV)in Lanzhou.Methods The real-time fluores-cent quantitative PCR was used to detect the HBV DNA load and the double antibody sandwich chemiluminesent immunoassay was used to measure the serum HBsAg,HbeAg,HbeAb and HbcAb levels in 724 cases of HBVinfection.Results The HBsAg level was positively correlated with the HBV DNA load in chronic HBV infection in Lanzhou area(r=0.342,P <0.05),there was an ob-vious positive correlation between HBeAg and HBV DNA load(r=0.463,P <0.05),the HBeAb level and HBV DNA load had the negative correlation (r=-0.227,P =0.001),the HBcAb level and HBV DNA load had no significantly correlation (r=-0.062, P =0.366).Conclusion There is obvious positive correlation between HBV DNA load with HBsAg,HBeAg in chronic HBV infec-tion in Lanzhou area,which indicating that the observation by combining HBsAg and HBeAg with HBV DNA can judge the infec-tious degree of the patients more accurately.