CAJ | 학술논문

目的：探索趋化因子CCL18在儿童过敏性疾病发生、发展过程中的作用。方法利用ELISA法对诊断为过敏性哮喘、过敏性鼻炎、过敏性眼结膜炎的患儿和同期健康体检学生的血清 CCL18水平进行检测，并在临床治疗6个月后重新复检该指标。结合临床相关检查资料，对检测结果采用 SPSS18．0统计软件进行分析，采用 t 检验，P ＜0．05为差异有统计学意义。结果过敏性哮喘、过敏性鼻炎和过敏性眼结膜炎3组患儿的 CCL18水平与健康对照组相比较，均明显升高，差异有统计学意义（P ＜0．05）；轻、中度和重症患儿两组比较，重症患儿组 CCL18水平升高的幅度明显高于轻、中度患儿组，差异有统计学意义（P ＜0．05）；治疗6个月后，3组患儿的 CCL18水平较治疗前均有明显的下降，差异有统计学意义（P ＜0．05）。结论CCL18水平与患儿病情的严重程度明显相关，治疗后明显下降，提示 CCL18的检测在过敏性患儿的病情诊断、病情严重程度的评估和治疗效果的监测过程中有着重要的临床价值。
목적：탐색추화인자CCL18재인동과민성질병발생、발전과정중적작용。방법이용ELISA법대진단위과민성효천、과민성비염、과민성안결막염적환인화동기건강체검학생적혈청 CCL18수평진행검측，병재림상치료6개월후중신복검해지표。결합림상상관검사자료，대검측결과채용 SPSS18．0통계연건진행분석，채용 t 검험，P ＜0．05위차이유통계학의의。결과과민성효천、과민성비염화과민성안결막염3조환인적 CCL18수평여건강대조조상비교，균명현승고，차이유통계학의의（P ＜0．05）；경、중도화중증환인량조비교，중증환인조 CCL18수평승고적폭도명현고우경、중도환인조，차이유통계학의의（P ＜0．05）；치료6개월후，3조환인적 CCL18수평교치료전균유명현적하강，차이유통계학의의（P ＜0．05）。결론CCL18수평여환인병정적엄중정도명현상관，치료후명현하강，제시 CCL18적검측재과민성환인적병정진단、병정엄중정도적평고화치료효과적감측과정중유착중요적림상개치。
Objective To explore the role of chemokine CCL18 in the occurrence and development of children allergic diseases. Methods The serum levels of CCL18 in 87 children cases of allergic asthma,64 cases of allergic rhinitis,46 cases of allergic con-junctivitis and contemporaneous 50 health students with physical examination as the control group were measured by ELISA and re-measured after 6-month treatment.The detection results were statistically analyzed with combining the clinical related detection data by adopting SPSS18.0 statistical software and t-test.Results The serum levels of CCL18 in the children allergic asthma,allergic rhinitis and allergic conjunctivitis groups were remarkably higher than those in the control group with statistical differences(P <0.05);the levels of CCL18 in the severe groups were remarkably higher than those in the mild and moderate groups with statistical difference(P <0.05);the levels of CCL18 after 6-month treatment in 3 groups were significantly decreased compared with before treatment with statistical difference(P <0.05).Conclusion The serum level of CCL18 is significantly associated with the severity of illness and significantly decreased after treatment,which indicating that the CCL18 detection has the important value in the diag-nosis,severity evaluation and treatment effect monitoring of children allergic diseases.