CAJ | 학술논문

目的：探讨慢性应激引起的抑郁样行为与海马神经细胞形态结构的变化。方法：建立慢性轻度不可预见性应激大鼠抑郁模型，检测大鼠快感缺乏，行为活动减少，体质量减轻等抑郁样症状，观察海马区病理改变。结果：实验组和对照组大鼠行为学评分存在显著差异(P<0.01)，实验组海马椎体细胞萎缩，神经细胞层数减少，细胞数目明显减少(P<0.01)。结论：应激可导致大鼠抑郁样行为的发生，同时影响神经细胞的生长和存活。
목적：탐토만성응격인기적억욱양행위여해마신경세포형태결구적변화。방법：건립만성경도불가예견성응격대서억욱모형，검측대서쾌감결핍，행위활동감소，체질량감경등억욱양증상，관찰해마구병리개변。결과：실험조화대조조대서행위학평분존재현저차이(P<0.01)，실험조해마추체세포위축，신경세포층수감소，세포수목명현감소(P<0.01)。결론：응격가도치대서억욱양행위적발생，동시영향신경세포적생장화존활。
Objective:To identify The Change in the neurons of Hippocampus of Rat and depressive-like behavior after Chronic Unpredictable Mild Stress ( CUMS). Method: The mice were subjected to various unpredictable stressors during the 21 days CUMS procedures. The depressive-like behavior and pathological change was observed.Results:The number of neurons of hippocampus after stress was significantly different (P<0.01).Conclusion:Rats after chronic unpredictable mild stress appeared depressive-like behavior correlated with decreased of neurons hippocampus.