CAJ | 학술논문

目的：比较牙龈和舌组织活检对淀粉样变性的诊断价值。方法回顾性分析2012年5月至2013年7月在北京协和医院口腔科同时行牙龈及舌组织活检的32例淀粉样变性患者临床资料。其中24例同期由外科行腹壁脂肪组织活检。活检标本由病理科常规制片，行HE染色和刚果红特染。结果组织活检病理示淀粉样变性在光镜下HE染色呈粉红色，刚果红染色呈砖红色；在偏振光显微镜下呈苹果绿双折射性。牙龈组织活检阳性22例，舌组织活检阳性23例，腹壁脂肪组织活检阳性19例。共29例经牙龈和舌组织活检确诊淀粉样变性，口腔组织活检阳性率为90.63％。经卡方检验，牙龈和舌组织活检对于淀粉样变性的检出结果差异无统计学意义（ P＞0.05）。结论牙龈和舌组织活检均可提供淀粉样变性病诊断重要依据。
목적：비교아간화설조직활검대정분양변성적진단개치。방법회고성분석2012년5월지2013년7월재북경협화의원구강과동시행아간급설조직활검적32례정분양변성환자림상자료。기중24례동기유외과행복벽지방조직활검。활검표본유병이과상규제편，행HE염색화강과홍특염。결과조직활검병리시정분양변성재광경하HE염색정분홍색，강과홍염색정전홍색；재편진광현미경하정평과록쌍절사성。아간조직활검양성22례，설조직활검양성23례，복벽지방조직활검양성19례。공29례경아간화설조직활검학진정분양변성，구강조직활검양성솔위90.63％。경잡방검험，아간화설조직활검대우정분양변성적검출결과차이무통계학의의（ P＞0.05）。결론아간화설조직활검균가제공정분양변성병진단중요의거。
Objective To evaluate and compare the diagnostic values of gingival and tongue biopsies in amyloidosis .Methods We retrospectively analyzed the clinical data of 32 amyloidosis patients who underwent gingival and tongue biopsies in Department of Stomatology of Peking Union Medical College Hospital from May 2012 to July 2013.Among them, 24 patients received abdominal fat biopsy in Department of General Surgery in the same period .Specimens were sliced in routine process , followed by staining with HE and Congo red .Results On light microscopy , amyloidosis was demonstrated as pink stains in HE staining , brick red in Congo red stai-ning, and in polarized light , apple-green birefringent deposits .Gingival biopsy was positive in 22 cases, tongue biopsy in 23 cases, and abdominal fat biopsy in 19 cases.In total, 29 amyloidosis cases were confirmed by gingi-val and tongue biopsies ( positive rate 90.63%) .Chi-squared test revealed no statistically significant difference between gingival biopsy and tongue biopsy in detecting amyloidosis ( P >0.05 ) .Conclusion Gingival and tongue biopsies can both provide solid diagnostic evidence in amyloidosis .