CAJ | 학술논문

目的：观察UBD蛋白在肝癌及其癌旁组织中的差异表达，探讨UBD对肝癌预后判断的指导意义。方法应用Realtime PCR和免疫组织化学染色等方法从基因水平和组织学水平对肝癌及癌旁组织进行UBD表达分析，并结合患者临床资料进行回顾性分析。结果通过基因水平和组织学水平检测发现UBD在肝癌中表达显著高于癌旁组织中的表达（P=0.001），进一步分析发现UBD表达与肝癌患者预后密切相关（χ2=3.955，P=0.047）。结论首次发现UBD在肝癌中高表达，且其表达水平影响肝癌患者的预后，是肝癌潜在的预后判断指标。
목적：관찰UBD단백재간암급기암방조직중적차이표체，탐토UBD대간암예후판단적지도의의。방법응용Realtime PCR화면역조직화학염색등방법종기인수평화조직학수평대간암급암방조직진행UBD표체분석，병결합환자림상자료진행회고성분석。결과통과기인수평화조직학수평검측발현UBD재간암중표체현저고우암방조직중적표체（P=0.001），진일보분석발현UBD표체여간암환자예후밀절상관（χ2=3.955，P=0.047）。결론수차발현UBD재간암중고표체，차기표체수평영향간암환자적예후，시간암잠재적예후판단지표。
Objective To observe the differential expression of UBD in HCC cancer tissue and peri-tumor tissue, and to explore its director significance on prognostic judgment. Methods Realtime PCR and immunohistochemical staining methods were used to measure the expression level of UBD in HCC tissues and its adjacent tissues and further retrospective statistical methods were used to analyze HCC patient prognosis combined with the clinical pathological data . Results Observe from the level of transcript and histological showed UBD high expression in HCC than adjacent tissues (P=0.001), UBD in HCC is particularly increased, further analysis revealed that patients with high expression of UBD experience poor prognosis(χ2=3.955, P=0.047). Conclusion We found UBD is highly expressed in HCC, and its expression levels in HCC has influenced the patients’ prognosis and maybe acts as the prognosis biomarker and target for HCC patients.