CAJ | 학술논문

解脲脲原体可导致盆腔炎、不良妊娠结局、非淋球菌性尿道炎、附睾炎等多种疾病.解脲脲原体有2个生物群14个血清型,但目前各种血清型之间致病性差异尚未明确.国内外使用小鼠、黑猩猩、羊等多种动物建立了宫内感染及下生殖道的感染模型,发现各型别感染后可导致IL-1、IL-6等多种炎症因子水平升高,子宫内膜及睾丸组织等均出现了不同程度的炎症浸润和变性等,不同部位感染率、感染时间均有不同.
해뇨뇨원체가도치분강염、불량임신결국、비림구균성뇨도염、부고염등다충질병.해뇨뇨원체유2개생물군14개혈청형,단목전각충혈청형지간치병성차이상미명학.국내외사용소서、흑성성、양등다충동물건립료궁내감염급하생식도적감염모형,발현각형별감염후가도치IL-1、IL-6등다충염증인자수평승고,자궁내막급고환조직등균출현료불동정도적염증침윤화변성등,불동부위감염솔、감염시간균유불동.
Ureaplasma urealyticum (Uu) is a common pathogen of genital tract infection,and can cause pelvic inflammatory diseases,adverse pregnancy outcomes,non-gonococcal urethritis,epididymitis,and so on.Uu is classified into 2 biovars and 14 serotypes,while the difference in pathogenicity among these serotypes remains unanswered.Animal models have been built for intrauterine infection and lower genital tract infection in mice,chimpanzee,goats,etc.It has been found that Uu infection can cause an increase in multiple cytokines such as interleukin (IL)-1 and IL-6,as well as different degrees of inflammatory infiltration and degeneration in endometrium and spermary.The incidence and duration of Uu infection vary with anatomical sites.