中西医结合肝病杂志
中西醫結閤肝病雜誌
중서의결합간병잡지
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE ON LIVER DISEASES
2014年
5期
265-267
,共3页
晚期肝癌%癌痛%中医外治法%吗啡缓释片/治疗应用%消痛散/治疗应用
晚期肝癌%癌痛%中醫外治法%嗎啡緩釋片/治療應用%消痛散/治療應用
만기간암%암통%중의외치법%마배완석편/치료응용%소통산/치료응용
late-stage liver cancer%cancer pain%TCM external therapy%morphine sustained release tablets/therapeutic application%Xiaotongsan/theraputic application
目的：探讨中医外治法对晚期肝癌癌痛的疗效。方法：将符合纳入标准的晚期肝癌癌痛患者82例随机分为两组：对照组42例，联合组40例。对照组患者按常规给予吗啡缓释片治疗，联合组患者在此基础上加用消痛散外敷。治疗4周后观察两组镇痛效果，进行视觉模拟疼痛评分（ VAS）及生活质量评分，并观察比较治疗前后吗啡用量的变化，同时记录不良反应。结果：治疗4周后，对照组显效率为64.3％，总有效率为69.0％；联合组显效率为75.0％，有效率为95.0％，联合组明显优于对照组，差异均有统计学意义（ P＜0.05）。与治疗前比较，两组VAS评分及生活质量评分均有改善，且联合组较对照组改善更为明显，差异有统计学意义（ P＜0.05）。相关性分析表明，患者VAS评分与生活质量评分呈负相关（r＝-0.75， P＝0.041），随着VAS评分的降低，患者生活质量显著改善。对照组治疗前后吗啡用量无显著变化，分别为（50.5±2.3） mg/d和（48.3±2.5） mg/d，而联合组治疗前后吗啡用量分别为（51.1±3.0） mg/d和（31.3±2.1） mg/d，差异有统计学意义（P＜0.05），且治疗组患者治疗后吗啡用量亦显著低于对照组（ P＜0.05）。结论：消痛散外敷联合吗啡缓释片可有效改善晚期肝癌患者的癌痛，提高患者生活质量，减少吗啡的用量，且无明显不良反应。
目的：探討中醫外治法對晚期肝癌癌痛的療效。方法：將符閤納入標準的晚期肝癌癌痛患者82例隨機分為兩組：對照組42例，聯閤組40例。對照組患者按常規給予嗎啡緩釋片治療，聯閤組患者在此基礎上加用消痛散外敷。治療4週後觀察兩組鎮痛效果，進行視覺模擬疼痛評分（ VAS）及生活質量評分，併觀察比較治療前後嗎啡用量的變化，同時記錄不良反應。結果：治療4週後，對照組顯效率為64.3％，總有效率為69.0％；聯閤組顯效率為75.0％，有效率為95.0％，聯閤組明顯優于對照組，差異均有統計學意義（ P＜0.05）。與治療前比較，兩組VAS評分及生活質量評分均有改善，且聯閤組較對照組改善更為明顯，差異有統計學意義（ P＜0.05）。相關性分析錶明，患者VAS評分與生活質量評分呈負相關（r＝-0.75， P＝0.041），隨著VAS評分的降低，患者生活質量顯著改善。對照組治療前後嗎啡用量無顯著變化，分彆為（50.5±2.3） mg/d和（48.3±2.5） mg/d，而聯閤組治療前後嗎啡用量分彆為（51.1±3.0） mg/d和（31.3±2.1） mg/d，差異有統計學意義（P＜0.05），且治療組患者治療後嗎啡用量亦顯著低于對照組（ P＜0.05）。結論：消痛散外敷聯閤嗎啡緩釋片可有效改善晚期肝癌患者的癌痛，提高患者生活質量，減少嗎啡的用量，且無明顯不良反應。
목적：탐토중의외치법대만기간암암통적료효。방법：장부합납입표준적만기간암암통환자82례수궤분위량조：대조조42례，연합조40례。대조조환자안상규급여마배완석편치료，연합조환자재차기출상가용소통산외부。치료4주후관찰량조진통효과，진행시각모의동통평분（ VAS）급생활질량평분，병관찰비교치료전후마배용량적변화，동시기록불량반응。결과：치료4주후，대조조현효솔위64.3％，총유효솔위69.0％；연합조현효솔위75.0％，유효솔위95.0％，연합조명현우우대조조，차이균유통계학의의（ P＜0.05）。여치료전비교，량조VAS평분급생활질량평분균유개선，차연합조교대조조개선경위명현，차이유통계학의의（ P＜0.05）。상관성분석표명，환자VAS평분여생활질량평분정부상관（r＝-0.75， P＝0.041），수착VAS평분적강저，환자생활질량현저개선。대조조치료전후마배용량무현저변화，분별위（50.5±2.3） mg/d화（48.3±2.5） mg/d，이연합조치료전후마배용량분별위（51.1±3.0） mg/d화（31.3±2.1） mg/d，차이유통계학의의（P＜0.05），차치료조환자치료후마배용량역현저저우대조조（ P＜0.05）。결론：소통산외부연합마배완석편가유효개선만기간암환자적암통，제고환자생활질량，감소마배적용량，차무명현불량반응。
Objective: To observe the therapeutic effect of TCM external therapy on late-stage liver cancer pain patients.Methods: Eighty-two late-stage liver cancer pain patients met the enrolled standard were randomly divided into 2 groups, 42 patients in control group and 40 patients in combined group.Patients in control group were given morphine sustained release tablets, patients in combined group were added Xiaotongsan external application, after 4-week treatment, the analgesic effect was observed in two groups, visual analogue score ( VAS) and life quality score were evaluated, changes of morphine dos-age before and after treatment were compared, at the same time, the side effect were recorded.Results: After 4 weeks treatment, the obvious effective rate in control group was 64.3%, total effective rate was 69.0%, while in combined group were 75.0%and 95.0%respectively.there were significance between the two groups ( P<0.05) .Compared with those before treatment, VAS score and life quality score in both groups were improved, combined group was more obvious than control group, there were significant difference ( P<0.05) .Correlation analysis showed that VAS score were positively correlated with life quality score (r=-0.75, P=0.041), the quality of life improved along with the decrease of VAS score.Dosage of morphine in control group changes were significantly before and after treatment, which were (50.5 ±2.3) mg/d and (48.3 ±2.5) mg/d, while in combined group they were (51.1 ±3.0) mg/d and (31.3 ±2.1) mg/d, there were significant difference (P<0.05) .Con-clusion: Xiaotongsan external application combining morphine sustained release tablets could effectively relieve the pain of late-stage liver cancer patients, improve their quality of life, decrease dosage of morphine, without no severe side effects.
