CAJ | 학술논문

目的：研究血清瘦素（ LEP）、性激素与非酒精性脂肪性肝病（ NAFLD）相关指标的关系，探讨杞荷祛脂方的疗效作用机制。方法：80例NAFLD患者随机分为A、 B两组，每组各40例，另40例健康志愿者作为对照组（C组）。 A组患者予杞荷祛脂方， B组患者口服水飞蓟宾胶囊，比较3组人员的临床、生化指标及瘦素、性激素水平。结果：①与C组比较， A、 B两组患者的LEP、雌二醇水平较高，总睾酮水平较低。血清LEP、雌二醇水平与NAFLD相关指标呈正相关，总睾酮与之呈负相关（ P＜0.01或P＜0.05）。②与治疗前比较，治疗后A、 B两组患者血清瘦素水平降低，差异有显著性意义（P＜0.05）；与B组比较， A组患者治疗后血清LEP更低（P＜0.01）。无论是治疗前和治疗后， A、 B两组患者雌二醇及总睾酮无明显改变（P＞0.05）。结论：杞荷祛脂方对NAFLD患者高血清瘦素水平有明显的调节作用，而对血清性激素无明显影响。
목적：연구혈청수소（ LEP）、성격소여비주정성지방성간병（ NAFLD）상관지표적관계，탐토기하거지방적료효작용궤제。방법：80례NAFLD환자수궤분위A、 B량조，매조각40례，령40례건강지원자작위대조조（C조）。 A조환자여기하거지방， B조환자구복수비계빈효낭，비교3조인원적림상、생화지표급수소、성격소수평。결과：①여C조비교， A、 B량조환자적LEP、자이순수평교고，총고동수평교저。혈청LEP、자이순수평여NAFLD상관지표정정상관，총고동여지정부상관（ P＜0.01혹P＜0.05）。②여치료전비교，치료후A、 B량조환자혈청수소수평강저，차이유현저성의의（P＜0.05）；여B조비교， A조환자치료후혈청LEP경저（P＜0.01）。무론시치료전화치료후， A、 B량조환자자이순급총고동무명현개변（P＞0.05）。결론：기하거지방대NAFLD환자고혈청수소수평유명현적조절작용，이대혈청성격소무명현영향。
Objective: To evaluate the relationship between serum leptin ( LEP) and sex hormone related indexes of nonal-coholic fatty liver disease ( NAFLD) , and observe the effect of Qi He Quzhi prescription on serum LEP and sex hormone levels in patients with NAFLD.Methods: Eighty cases of NAFLD patients were randomly divided into group A and group B, another 40 healthy volunteers as control group ( group C) .Group A was treated by Qi He Quzhi prescription, group B was given silibinin capsules, recording all of clinical and biochemical indexes.Results: ①Compared with group C, the LEP and estradiol levels of group A and B were more higher, total testosterone level was more lower.The high serum LEP, estradiol levels were positive re-lated to the NAFLD relationship indexs, but total testosterone no negative related to it (P<0.01 or P<0.05) .②Compared with before treatment, the levels of serum LEP was decreased after treatment in group A and B, there was significant difference (P<0.05) .Compared with group B, in group A serum levels of LEP more lower after treatment (P<0.01) .Whether before or after the treatment, estradiol and testosterone levels were no obvious change in group A and B (P>0.05) .Conclusion: Qi He Quzhi prescription has obvious regulating effect on serum LEP but sex hormone in NAFLD patients.