中西医结合肝病杂志
中西醫結閤肝病雜誌
중서의결합간병잡지
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE ON LIVER DISEASES
2014年
5期
259-261
,共3页
王成宝%陈逸云%聂红明%吕桦%李泓町%陈建杰
王成寶%陳逸雲%聶紅明%呂樺%李泓町%陳建傑
왕성보%진일운%섭홍명%려화%리홍정%진건걸
肝炎, 丙型, 慢性%病毒基因型%中医证候%循证医学
肝炎, 丙型, 慢性%病毒基因型%中醫證候%循證醫學
간염, 병형, 만성%병독기인형%중의증후%순증의학
chronic hepatitis C%virus genotype%traditional Chinese medicine syndrome%evidence-based medicine
目的:探讨慢性丙型肝炎( CHC)中医证候与病毒基因型的关系。方法:采用问卷调查与实验室检测相结合的形式,统计患者的中医症候体征规律,丙型肝炎病毒( HCV)基因分型采用基因测序法检测,采用Logistic回归进行相关性分析。结果:我国CHC患者病毒基因型以1型为主,中医证型以正虚邪恋型为主,病毒基因型和中医证型间不存在相关性,临床症状胁肋隐痛与HCV基因型存在相关性,且症状越重,病毒基因1、6型出现的机率越大。结论: HCV患者临床宏观症状与微观指标之间可能存在某些联系,该结果将为进一步研究CHC的宏观与微观之间的联系提供流行病学依据。
目的:探討慢性丙型肝炎( CHC)中醫證候與病毒基因型的關繫。方法:採用問捲調查與實驗室檢測相結閤的形式,統計患者的中醫癥候體徵規律,丙型肝炎病毒( HCV)基因分型採用基因測序法檢測,採用Logistic迴歸進行相關性分析。結果:我國CHC患者病毒基因型以1型為主,中醫證型以正虛邪戀型為主,病毒基因型和中醫證型間不存在相關性,臨床癥狀脅肋隱痛與HCV基因型存在相關性,且癥狀越重,病毒基因1、6型齣現的機率越大。結論: HCV患者臨床宏觀癥狀與微觀指標之間可能存在某些聯繫,該結果將為進一步研究CHC的宏觀與微觀之間的聯繫提供流行病學依據。
목적:탐토만성병형간염( CHC)중의증후여병독기인형적관계。방법:채용문권조사여실험실검측상결합적형식,통계환자적중의증후체정규률,병형간염병독( HCV)기인분형채용기인측서법검측,채용Logistic회귀진행상관성분석。결과:아국CHC환자병독기인형이1형위주,중의증형이정허사련형위주,병독기인형화중의증형간불존재상관성,림상증상협륵은통여HCV기인형존재상관성,차증상월중,병독기인1、6형출현적궤솔월대。결론: HCV환자림상굉관증상여미관지표지간가능존재모사련계,해결과장위진일보연구CHC적굉관여미관지간적련계제공류행병학의거。
Objective: To evaluate the relationship between chronic hepatitis C virus genotype and traditional Chinese med-icine syndrome.Methods: This study adopted the combining form of the questionnaire investigation and laboratory tests, record-ing the patient′s symptoms and signs of traditional Chinese medicine and so on, gene sequencing method was applied to detect chronic hepatitis C virus genotype, and all the data were analyzed with Logistic regression analysis.Results: Chronic hepatitis C virus genotype in China was dominanted with type 1 and type of syndrome was similar with deficient vital Qi with residuary pathogen.There was no correlation between virus genotype and TCM syndrome type.However, there was an association between indistinct pain over hypochondrium and hepatitis C virus genotype, and virus genotype 1, 6 occurrence probability increases with the symptom aggravating.Conclusion: There may be some contact between the clinical symptoms of macroscopic and microcos-mic indexes in patients with chronic hepatitis C, and it will provide basis for further epidemiological studies of chronic hepatitis C between the macroscopic symptom and the microcosmic index.