CAJ | 학술논문

目的：比较单纯放疗与同期放化疗治疗中晚期鼻咽癌的临床效果及安全性。方法回顾性分析我院收治的120例中晚期鼻咽癌患者的临床资料，根据治疗方法的不同分为4组：A组（单纯放疗）、B组（放疗联合紫杉醇同期化疗）、C组（放疗联合替加氟同期化疗）、D组（放疗联合紫杉醇+替加氟化疗），每组各30例患者。比较各组的近期治疗总有效率、5年总生存率及治疗过程中不良反应的发生情况。结果 B、C、D组的治疗总有效率和5年总生存率均明显高于A组；A组患者各项毒副反应的发生率均明显低于同期B、C、D组；D组发生毒副反应的比率明显高于B、C组；B组和C组发生毒副反应的比率无显著性差异（P>0.05）。结论同期放化疗治疗中晚期鼻咽癌的临床效果优于单纯放疗，单一或联合药物同期放化疗的临床效果相当，但单一药物同期放化疗的安全性更高，值得临床推广应用。
목적：비교단순방료여동기방화료치료중만기비인암적림상효과급안전성。방법회고성분석아원수치적120례중만기비인암환자적림상자료，근거치료방법적불동분위4조：A조（단순방료）、B조（방료연합자삼순동기화료）、C조（방료연합체가불동기화료）、D조（방료연합자삼순+체가불화료），매조각30례환자。비교각조적근기치료총유효솔、5년총생존솔급치료과정중불량반응적발생정황。결과 B、C、D조적치료총유효솔화5년총생존솔균명현고우A조；A조환자각항독부반응적발생솔균명현저우동기B、C、D조；D조발생독부반응적비솔명현고우B、C조；B조화C조발생독부반응적비솔무현저성차이（P>0.05）。결론동기방화료치료중만기비인암적림상효과우우단순방료，단일혹연합약물동기방화료적림상효과상당，단단일약물동기방화료적안전성경고，치득림상추엄응용。
Objective To investigate the clinical effects and safety of radiotherapy and concurrent chemotherapy for patients with advanced nasopharyngeal carcinoma. Methods A retrospective analysis were carried out on the clinical data of 120 cases of advanced nasopharyngeal carcinoma patients in our hospital. According to the different treating ways, they were divided into four groups:group A with radiotherapy alone, group B with radiotherapy and concomitant paclitaxel chemotherapy, group C with radiotherapy and concomitant tegafur chemotherapy, group D with radiotherapy plus paclitaxel and tegafur chemotherapy. Each group had 30 patients. We observed and compared the therapeutic group's total effective rate, 5-year overall survival rate and adverse reaction during the treatment situation. Results The total effective rate and 5-year overall survival rate in group B, C, D were significantly higher than those in group A. The incidence of toxic reactions of group A was significantly lower than that of group B, C, D during the same period, and that of group B and C was also significantly lower than that of group D (P<0.05) but there were no significant differences between the group B and C (P>0.05). Conclusion Radiotherapy plus concurrent chemotherapy had better clinical effect for advanced nasopharyngeal carcinoma patients than radiotherapy alone. The radio-therapy plus single-drug chemotherapy had equal clinical effects with the radiotherapy plus combined-drug chemotherapy, but the former had better security and thus was worthy of clinical application.