CAJ | 학술논문

目的：观察中医活血祛瘀法联合盐酸羟考酮缓释片（OXY）控制中重度癌痛的临床疗效及安全性。方法将46例合格纳入对象分为治疗组24例和对照组22例。所有病例均进行羟考酮缓释片剂量滴定。治疗组同时采用化瘀方汤药内服、双柏散外敷和疏血通注射液静脉滴注。比较治疗组与对照组在疼痛控制及不良反应上的差异。结果羟考酮（OXY）滴定过程显示，治疗组及对照组在初始剂量、OXY起效时间、观察期内OXY最大剂量上无明显差异（P>0.05），而在OXY维持剂量、滴定达维持剂量时间的差异均有统计学意义（P<0.05）。组间比较发现，治疗组NRS、PID评分下降较对照组明显，但差异无统计学意义（P>0.05）。结论中医活血化瘀法可能减少阿片类药物的维持剂量、缩短滴定达维持剂量时间，但不降低阿片类药物初始剂量、观察期内最大剂量和缩短起效时间。
목적：관찰중의활혈거어법연합염산간고동완석편（OXY）공제중중도암통적림상료효급안전성。방법장46례합격납입대상분위치료조24례화대조조22례。소유병례균진행간고동완석편제량적정。치료조동시채용화어방탕약내복、쌍백산외부화소혈통주사액정맥적주。비교치료조여대조조재동통공제급불량반응상적차이。결과간고동（OXY）적정과정현시，치료조급대조조재초시제량、OXY기효시간、관찰기내OXY최대제량상무명현차이（P>0.05），이재OXY유지제량、적정체유지제량시간적차이균유통계학의의（P<0.05）。조간비교발현，치료조NRS、PID평분하강교대조조명현，단차이무통계학의의（P>0.05）。결론중의활혈화어법가능감소아편류약물적유지제량、축단적정체유지제량시간，단불강저아편류약물초시제량、관찰기내최대제량화축단기효시간。
Objective To evaluate the efficacy and safety of oxycodone hydrochloride controlled-release tables (OXY) com-bined with the method of invigorating the circulation of blood and removing stasis in treatment of moderate or severe cancer pain. Methods A total of 46 patients who have cancer pain that need to take opoids were included. They were randomized into treat-ment group (24 cases) and control group (22 cases). All cases had oxycodone hydrochloride controlled-release tables. Patients in treatment group were added with traditional Chinese medicine therapy. They had oral administration of dispersing blood-stasis decoction, external application of Shuangbosan and intravenous infusion of Shuxuetong. Compare the difference of pain control and adverse reactions between the two groups. Results Through the observation in titration process, there were no significant differences between the treatment group and the control group in the initial dose, onset time and OXY maximum dose during ob-servation period (P>0.05). However, the maintenance dose and the time reaching to maintenance dose were significantly differ-ent between the two groups (P>0.05). Moreover, the NRS and PID score declined more in the treatment group than in the control group, but the difference has no statistical significance (P>0.05). Conclusion The traditional Chinese method of invigorating the circulation of blood and removing stasis would reduce the maintenance dose of opioids and shorten the time to approach mainte-nance dose but does not affect the initial dose of opioid drugs, the onset time or maximum dose within the observation period.