CAJ | 학술논문

多种恶性肿瘤细胞中表达细胞凋亡抑制蛋白（IAPs），如：Survivin、NAIP、XIAP、Livin等，同样表达抗细胞凋亡Bcl-2家族蛋白。IAPS介导的凋亡抑制可能是肿瘤细胞耐药而存活的原因之一；Bcl-2家族蛋白在抗肿瘤凋亡及促其凋亡中发挥作用。姜黄素具有抗炎、抗氧化、抑制血管新生等，可以通过调控蛋白表达及相关信号通路促进细胞凋亡、抗肿瘤作用。
다충악성종류세포중표체세포조망억제단백（IAPs），여：Survivin、NAIP、XIAP、Livin등，동양표체항세포조망Bcl-2가족단백。IAPS개도적조망억제가능시종류세포내약이존활적원인지일；Bcl-2가족단백재항종류조망급촉기조망중발휘작용。강황소구유항염、항양화、억제혈관신생등，가이통과조공단백표체급상관신호통로촉진세포조망、항종류작용。
A variety of tumor cells have expression of the inhibitor of apoptosis proteins (IAPs) such as survivin, NAIP, XIAP and Livin protein, as well as expression of resistance-to-apoptosis Bcl-2 family protein. The apoptosis inhibition mediated by IAPS may be one of the reasons for drug-resistant tumor cell and its survival. The Bcl-2 family proteins also play a role in anti-tumor apoptosis and promote their apoptosis proteins. Curcumin has functions like anti-inflammatory, antioxidant, inhibition of angiogenesis and so on. It can promote cell apoptosis and strengthen the antitumor effects through its regulation of protein expressions and related signaling pathways.