CAJ | 학술논문

目的：研究3种不同药物方案治疗幽门螺杆菌（Helicobacter Pylor ，HP）的根除疗效及经济成本。方法：180例HP患者随机分成A、B、C 3组，A组给以替那拉唑10mg＋阿莫西林1000mg＋克拉霉素500mg；B组给以兰索拉唑10mg＋呋喃西林100mg＋卡那霉素500mg；C组给以胶体果胶铋200mg＋培氟沙星200mg＋羧苄西林1000mg；3组均口服，2次/日，疗程均为7天。治疗4周后胃镜复查和14 C呼气试验，比较根除率，并对成本效果比（C/E ）和增量成本-效果比（△C/△E ）分析。结果：ITT分析和PP分析根除率，发现C组与A、B组相比较差异有统计学意义（ P＜0.05）；ITT和PP分析C/E ，证明C组所需成本最低，且相对于A组，C组△C/△E较B组低，表明在同等疗效前提下所需的成本较小。结论：胶体果胶铋、培氟沙星、羧苄西林药物联用疗法更符合理想的HP根除方案要求，高效、安全、经济，适用于临床应用。
목적：연구3충불동약물방안치료유문라간균（Helicobacter Pylor ，HP）적근제료효급경제성본。방법：180례HP환자수궤분성A、B、C 3조，A조급이체나랍서10mg＋아막서림1000mg＋극랍매소500mg；B조급이란색랍서10mg＋부남서림100mg＋잡나매소500mg；C조급이효체과효필200mg＋배불사성200mg＋최변서림1000mg；3조균구복，2차/일，료정균위7천。치료4주후위경복사화14 C호기시험，비교근제솔，병대성본효과비（C/E ）화증량성본-효과비（△C/△E ）분석。결과：ITT분석화PP분석근제솔，발현C조여A、B조상비교차이유통계학의의（ P＜0.05）；ITT화PP분석C/E ，증명C조소수성본최저，차상대우A조，C조△C/△E교B조저，표명재동등료효전제하소수적성본교소。결론：효체과효필、배불사성、최변서림약물련용요법경부합이상적HP근제방안요구，고효、안전、경제，괄용우림상응용。
Objective]To study the clinical efficacy and economic cost of three drug treatment projects ofhelicobacter pylori (HP) eradication .[Method]One hundred and eighty HP patients were randomly divided into three groups ,group A ,group B and group C .10 mg tenprazole and 1000 mg amoxicillin (Huameihua , Wuhan ) and 500 mg clarithromycin were applied in group A ,10 mg lansoprazole and 100 mg furacilin and 500 mg kanamycin were applied in group B ,200 mg colloidal bismuth pectin and 200 mg pefloxacin and 1000 mg carbenicillin were applied in group C ,which were took via orally twice a day and all the times of therapy were 7 days;Stomachoscopy gastroscopy and 14C-urea breath test were applied to compare the elimina-tion rate 4 weeks after drug treatment .C/E and△C/△E were evaluated .[Result]Eradication rates analyzed by ITTand PP demonstrated group C were obviously higher than groups A and B ( P<0.05 ) .C/E revealed by ITT and PP demonstrated the cost of group C was lowest .The smaller value of △C/△E in group C suggested a lower cost under the precondition achieving equivalent efficacy ,using the group A as control .[Conclusion ]Combination of colloidal bismuth pectin , pefloxacin and car-benicillin was more suitable as the ideal project on HP eradication in clinical ,which was proved to be effective ,safe and eco-nomical .