CAJ | 학술논문

目的：探讨右丙亚胺对行吡柔比星化疗乳腺癌患者的心脏保护作用。方法选择行吡柔比星药物化疗的乳腺癌患者80例，随机分为两组，各40例，其中观察组接受TAC（多西他赛＋吡柔比星＋环磷酰胺）方案加右丙亚胺静脉滴注，右丙亚胺的配制浓度为吡柔比星的10倍；对照组常规接受TAC方案加安慰剂治疗。分析并比较两组患者间不同治疗阶段的心电图、左室射血分数及不良反应。结果两组患者心电图异常差异、左室射血分数从第4周开始均有统计学意义（P＜0．05）；观察组在治疗前及治疗后1年随访期间，左室射血分数差异无统计学意义（P＞0．05），观察组治疗期间消化道反应、脱发的发生率均明显低于对照组（P＜0．05）。结论右丙亚胺能提高行含吡柔比星药物化疗的乳腺癌患者的心脏耐受性，减少不良反应。
목적：탐토우병아알대행필유비성화료유선암환자적심장보호작용。방법선택행필유비성약물화료적유선암환자80례，수궤분위량조，각40례，기중관찰조접수TAC（다서타새＋필유비성＋배린선알）방안가우병아알정맥적주，우병아알적배제농도위필유비성적10배；대조조상규접수TAC방안가안위제치료。분석병비교량조환자간불동치료계단적심전도、좌실사혈분수급불량반응。결과량조환자심전도이상차이、좌실사혈분수종제4주개시균유통계학의의（P＜0．05）；관찰조재치료전급치료후1년수방기간，좌실사혈분수차이무통계학의의（P＞0．05），관찰조치료기간소화도반응、탈발적발생솔균명현저우대조조（P＜0．05）。결론우병아알능제고행함필유비성약물화료적유선암환자적심장내수성，감소불량반응。
Objective To explore the cardio-protective effect of dexrazoxane injection for breast cancer pa-tients under theprubicin chemotherapy treatment. Methods 80 cases of breast cancer patients under theprubi-cin chemotherapy were randomly divided into two groups,40 cases in each group. Patients in the observation group were given TAC (taxotere+theprubicin+ cyclophosphamide)and dexrazoxane injection,the allocation ratio of dexrazoxane injection was 10 times of theprubicin,and patients in the control group were given TAC and placebos. Electro-cardiogram,left ventricular ejection fraction (LVEF)and adverse reactions at different treat-ment stages in the two groups were analyzed and compared accordingly. Results There were abnormal differ-ences of electro-cardiogram in 2 groups and LVEF changes were statistically significant (P<0. 05). During the start of treatment and one year follow-up period after treatment,the LVEF of observation group had no significant difference(P>0. 05),the gastrointestinal reactions,occurrences of alopecia in the observation group at treatment phase were less than those in control group (P <0. 05). Conclusion Dexrazoxane injection can improve cardi-ac resistance effect of breast cancer patients who were under theprubicin-containing chemotherapy and reduce their adverse reaction.