中国肿瘤外科杂志
中國腫瘤外科雜誌
중국종류외과잡지
CHINESE MEDICAL DIGEST SURGERY
2014年
5期
279-281
,共3页
鼻咽癌%化疗%放疗%复方苦参注射液
鼻嚥癌%化療%放療%複方苦參註射液
비인암%화료%방료%복방고삼주사액
nasopharyngeal carcinoma%chemoradiotherapy%radiotherapy%compound Kushen injection
目的:评价复方苦参注射液联合NP化疗方案及同步适形调强放疗对局部晚期鼻咽癌的疗效和毒副作用。方法将2006年1月至2009年1月112例经病理学或细胞学证实的局部晚期鼻咽癌随机分为2组,对照组采用NP方案化疗,同时给予鼻咽+颈部适形调强放疗。观察组在放化疗的基础上加用复方苦参注射液(15 ml静脉滴注,1次/d,连续2周为一周期)。结果两组随访率为100%,两组的1、3、5年总生存率,1、3、5年无复发生存率,1、3、5年无转移生存率,1、3、5年无瘤生存率差异均无统计学意义(均P>0.05)。观察组与对照组相比,Ⅲ、Ⅳ度白细胞减少、急性黏膜反应及颈皮炎均明显减少(均P<0.05)。结论复方苦参注射液联合NP方案和同步适形调强放疗能降低局部晚期鼻咽癌的毒副作用。
目的:評價複方苦參註射液聯閤NP化療方案及同步適形調彊放療對跼部晚期鼻嚥癌的療效和毒副作用。方法將2006年1月至2009年1月112例經病理學或細胞學證實的跼部晚期鼻嚥癌隨機分為2組,對照組採用NP方案化療,同時給予鼻嚥+頸部適形調彊放療。觀察組在放化療的基礎上加用複方苦參註射液(15 ml靜脈滴註,1次/d,連續2週為一週期)。結果兩組隨訪率為100%,兩組的1、3、5年總生存率,1、3、5年無複髮生存率,1、3、5年無轉移生存率,1、3、5年無瘤生存率差異均無統計學意義(均P>0.05)。觀察組與對照組相比,Ⅲ、Ⅳ度白細胞減少、急性黏膜反應及頸皮炎均明顯減少(均P<0.05)。結論複方苦參註射液聯閤NP方案和同步適形調彊放療能降低跼部晚期鼻嚥癌的毒副作用。
목적:평개복방고삼주사액연합NP화료방안급동보괄형조강방료대국부만기비인암적료효화독부작용。방법장2006년1월지2009년1월112례경병이학혹세포학증실적국부만기비인암수궤분위2조,대조조채용NP방안화료,동시급여비인+경부괄형조강방료。관찰조재방화료적기출상가용복방고삼주사액(15 ml정맥적주,1차/d,련속2주위일주기)。결과량조수방솔위100%,량조적1、3、5년총생존솔,1、3、5년무복발생존솔,1、3、5년무전이생존솔,1、3、5년무류생존솔차이균무통계학의의(균P>0.05)。관찰조여대조조상비,Ⅲ、Ⅳ도백세포감소、급성점막반응급경피염균명현감소(균P<0.05)。결론복방고삼주사액연합NP방안화동보괄형조강방료능강저국부만기비인암적독부작용。
Objective To investigate the result and side effect of Compound Kushen injection combined with NP regiment concurrent chemoradiotherapy (IMRT)for 112 patients with locally advanced nasopharyngeal carcinoma. Methods From January 2006 to January 2009,112 patients with locally advanced nasopharyngeal carcinoma were divided into 2 groups,i. e,the observation and control group. In the observation group,the pa-tients were gived NP regiment concurrent chemoradiotherapy(IMRT). In the control group,Compound Kushen injection combined with concurrent radiochemotherapy was given 15 ml once a day for 14 days. Results The follow up rate were 100% in the two groups. The 1-,3-and 5-year overall survival rates,locoregional relapse-free survival rates,distant metastasis-free survival rates,disease-free-survival rates were no difference between two groups. There were fewer patients who had overall leukopenia and thrombocytopenia decline,acute mucosi-tis and neck dermatitis with 3 and 4 grade in control group compared with observion group. Conclusions Com-pound Kushen injection combined with NP regiment concurrent chemoradiotherapy for advanced NPC can a-chieve fine result in clinical response and and effect is clinically acceptable.