CAJ | 학술논문

目的：分析泛发性脓疱型银屑病（ GPP）的发病诱因、临床表现及治疗方法。方法：回顾性分析28例GPP患者的临床资料及治疗过程。结果：多种因素可导致GPP发病，其中感染、不规则使用皮质类固醇激素是诱发和加重GPP的主要因素。发热是其最常见、突出的全身症状。实验室检查中白细胞升高、血沉升高者占多数。采用第二代维A酸类药物（阿维A）、免疫抑制剂（甲氨蝶呤，MTX）、阿维A联合糖皮质激素、MTX联合糖皮质激素四种治疗方案治疗GPP均取得了良好的疗效。结论：四种治疗方案均能有效治疗GPP。采用何种治疗方案，需根据病情的严重程度、复发情况、治疗药物的敏感性、副作用和耐受情况个体化而定。
목적：분석범발성농포형은설병（ GPP）적발병유인、림상표현급치료방법。방법：회고성분석28례GPP환자적림상자료급치료과정。결과：다충인소가도치GPP발병，기중감염、불규칙사용피질류고순격소시유발화가중GPP적주요인소。발열시기최상견、돌출적전신증상。실험실검사중백세포승고、혈침승고자점다수。채용제이대유A산류약물（아유A）、면역억제제（갑안접령，MTX）、아유A연합당피질격소、MTX연합당피질격소사충치료방안치료GPP균취득료량호적료효。결론：사충치료방안균능유효치료GPP。채용하충치료방안，수근거병정적엄중정도、복발정황、치료약물적민감성、부작용화내수정황개체화이정。
Objective:To investigate the pathogenesis , the clinical manifestation , and the treatment of generalized pustular psoriasis ( GPP ) .Methods:The clinical data and treatment process of 28 patients with GPP were retrospective analysed .Results:Many factors could lead to GPP.Infection and irregular use of corticosteroids were the main factors inducing and aggravating GPP.Fever was the common and distinctive systemic symptoms .The elevation in white blood cell counts and ESR were the main laboratory manifestations .The regiments of second generation retin-oic acid ( acitretin ) , immunosuppressant ( methotrexate , MTX ) , acitretin combined with glu-cocorticoid, MTX combined with glucocorticoid had good therapeutic effect on GPP .Conclusion:All of four therapy regiments had good therapeutic effect on GPP .The therapy program should be applied based on the severity of disease , drug effecacy , side effects and tolerance .