CAJ | 학술논문

目的：研究MMP1基因单核苷酸多态(-1607)1G/2G与环孢素诱导牙龈增生(C泽A-GO)发生风险的关系。方法以聚合酶链反应和限制性片段长度多态性(PCR-RFLP)分析方法，分别检测42例环孢素诱导牙龈增生病人和118位正常对照者MMP1(-1607)1G/2G多态的基因型；以Logistic回归模型计算不同基因型与环孢素诱导牙龈增生风险的关系。结果环孢素诱导牙龈增生病例组的MMP1(-1607)3种基因型频率分布与对照组无显著差异(P=0.37)。携带MMP1(-1607)2G基因型者发生环孢素诱导牙龈增生的风险比携带1G基因型者高1.38倍(95%CI=0.81~2.36，P=0.24)，而1G基因型与环孢素诱导牙龈增生风险无关。结论MMP1基因启动子区(-1607)1G/2G单核苷酸多态性可能并非环孢素诱导牙龈增生的遗传易感因素，携带2G基因型的患者发生CsA-GO的风险有增高趋势。
목적：연구MMP1기인단핵감산다태(-1607)1G/2G여배포소유도아간증생(C택A-GO)발생풍험적관계。방법이취합매련반응화한제성편단장도다태성(PCR-RFLP)분석방법，분별검측42례배포소유도아간증생병인화118위정상대조자MMP1(-1607)1G/2G다태적기인형；이Logistic회귀모형계산불동기인형여배포소유도아간증생풍험적관계。결과배포소유도아간증생병례조적MMP1(-1607)3충기인형빈솔분포여대조조무현저차이(P=0.37)。휴대MMP1(-1607)2G기인형자발생배포소유도아간증생적풍험비휴대1G기인형자고1.38배(95%CI=0.81~2.36，P=0.24)，이1G기인형여배포소유도아간증생풍험무관。결론MMP1기인계동자구(-1607)1G/2G단핵감산다태성가능병비배포소유도아간증생적유전역감인소，휴대2G기인형적환자발생CsA-GO적풍험유증고추세。
Objective To study the relationship between single nucleotide polymorphisms of MMP1 gene (-1607) and cyclosporine-induced gingival overgrowth ( CsA-GO ) . Methods Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to detect 42 cases of cyclosporine-induced gingival hyperplasia patients and 118 normal controls. MMP1 (-1607) 1G/2G gene polymorphism type were detected and analysised;Logistic regres-sion model was used to calculate the different genotypes and the risk of cyclosporine-induced gingival hyperplasia re-lationship. Results Cyclosporine-induced MMP1 (-1607) 3 genotype frequency distribution of gingival hyperplasiacase group had no significant difference (P=0.37) with the control group. Patients who carry MMP1 (-1607) 2G genotype occurred cyclosporine-induced gingival hyperplasia have 1.37 times risk than 1G genotype (95%CI=0.81-2.36, P=0.24), and 1G genotype and cyclosporine-inducedgingival hyperplasiaun related torisk. Conclusion MMP1 gene promoter region (-1607) 1G/2G single nucleotide polymorphism of cyclosporine -induced gingival hyperplasia may not a genetic susceptibility factor, patients who carry 2G genotype has an increased risk of CsA-GO.