中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2014年
30期
58-60,63
,共4页
袁满春%赵锋%刘志伟%杨敏春
袁滿春%趙鋒%劉誌偉%楊敏春
원만춘%조봉%류지위%양민춘
中医辨证分型%慢性乙型肝炎%T淋巴细胞亚群%VCS参数
中醫辨證分型%慢性乙型肝炎%T淋巴細胞亞群%VCS參數
중의변증분형%만성을형간염%T림파세포아군%VCS삼수
Chinese medicine dialectical sub-typing%Chronic hepatitis B%T cell subsets%VCS parameters
目的:探讨慢性乙型肝炎患者不同的中医辨证分型是否引起淋巴细胞亚群和淋巴细胞VCS (V volume C conductivity S scatter)相应的变化。方法对符合纳入条件116病例分成三组,分别为肝郁脾虚型43例,湿热中阻型38例,瘀血阻络型35例,同时选健康体检人员为健康对照组48例。对各组进行ALT、WBC、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC、MLC-SD、MLS、MLS-SD的检测,分析各组上述指标间的相互关系。结果与健康对照组比较,肝郁脾虚型、湿热中阻型、瘀血阻络型三组的ALT、CD8+、MLV、MLV-SD、MLC-SD、MLS-SD均升高,差异有统计学意义(P<0.05),WBC、CD4+、CD4+/CD8+、MLC、MLS均下降,差异有统计学意义(P<0.05),与湿热中阻型比较,肝郁脾虚型的CD8+、MLV-SD、MLC-SD、MLS、MLS-SD差异有统计学意义(P<0.05),瘀血阻络型ALT、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC-SD、MLS差异有统计学意义(P<0.05),与瘀血阻络型比较,ALT、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC-SD、MLC-SD、MLS、MLS-SD差异有统计学意义(P<0.05)。结论慢性乙型肝炎患者证侯的变化,淋巴细胞的亚群表达及VCS参数的结果发生相应的变化,表明三者间存在密切的关系,可为中医辨证分型提供实验指标。
目的:探討慢性乙型肝炎患者不同的中醫辨證分型是否引起淋巴細胞亞群和淋巴細胞VCS (V volume C conductivity S scatter)相應的變化。方法對符閤納入條件116病例分成三組,分彆為肝鬱脾虛型43例,濕熱中阻型38例,瘀血阻絡型35例,同時選健康體檢人員為健康對照組48例。對各組進行ALT、WBC、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC、MLC-SD、MLS、MLS-SD的檢測,分析各組上述指標間的相互關繫。結果與健康對照組比較,肝鬱脾虛型、濕熱中阻型、瘀血阻絡型三組的ALT、CD8+、MLV、MLV-SD、MLC-SD、MLS-SD均升高,差異有統計學意義(P<0.05),WBC、CD4+、CD4+/CD8+、MLC、MLS均下降,差異有統計學意義(P<0.05),與濕熱中阻型比較,肝鬱脾虛型的CD8+、MLV-SD、MLC-SD、MLS、MLS-SD差異有統計學意義(P<0.05),瘀血阻絡型ALT、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC-SD、MLS差異有統計學意義(P<0.05),與瘀血阻絡型比較,ALT、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC-SD、MLC-SD、MLS、MLS-SD差異有統計學意義(P<0.05)。結論慢性乙型肝炎患者證侯的變化,淋巴細胞的亞群錶達及VCS參數的結果髮生相應的變化,錶明三者間存在密切的關繫,可為中醫辨證分型提供實驗指標。
목적:탐토만성을형간염환자불동적중의변증분형시부인기림파세포아군화림파세포VCS (V volume C conductivity S scatter)상응적변화。방법대부합납입조건116병례분성삼조,분별위간욱비허형43례,습열중조형38례,어혈조락형35례,동시선건강체검인원위건강대조조48례。대각조진행ALT、WBC、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC、MLC-SD、MLS、MLS-SD적검측,분석각조상술지표간적상호관계。결과여건강대조조비교,간욱비허형、습열중조형、어혈조락형삼조적ALT、CD8+、MLV、MLV-SD、MLC-SD、MLS-SD균승고,차이유통계학의의(P<0.05),WBC、CD4+、CD4+/CD8+、MLC、MLS균하강,차이유통계학의의(P<0.05),여습열중조형비교,간욱비허형적CD8+、MLV-SD、MLC-SD、MLS、MLS-SD차이유통계학의의(P<0.05),어혈조락형ALT、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC-SD、MLS차이유통계학의의(P<0.05),여어혈조락형비교,ALT、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC-SD、MLC-SD、MLS、MLS-SD차이유통계학의의(P<0.05)。결론만성을형간염환자증후적변화,림파세포적아군표체급VCS삼수적결과발생상응적변화,표명삼자간존재밀절적관계,가위중의변증분형제공실험지표。
Objective To investigate the changes of T cell subsets VCS caused by different syndrome types in patients with Chronic Hepatitis B (CHB). Methods A total of 116 samples were enrolled in the study, which were divided into 3 groups:43 CHB patients of liver depressions and spleen deficiency type, 38 of damp-heat type and 35 of blood stasis type. 48 healthy people were also included as normal control. ALT, WBC, CD4+, CD8+, CD4+/CD8+, MLV, MLV-SD, MLC, MLC-SD, MLS and MLS-SD of the 4 groups were tested and analyzed. Results ALT, CD8+, MLV, MLV-SD, MLC-SD and MLS-SD of CHB patients of liver depression and spleen deficiency type, damp-heat type and blood stasis type were significantly increased compared with normal group (P<0.05), however, WBC, CD4+, CD4+/CD8+, MLC and MLS were decreased apparently (P<0.05). CD8+, MLV-SD, MLC-SD, MLS and MLS-SD were significantly different between damp-heat type and liver depressions and spleen deficiency type (P<0.05). ALT, CD4+, CD8+, CD4+/CD8+, MLV, MLV-SD, MLC-SD and MLS were distinct between damp-heat type and blood stasis type (P<0.05). Conclusion T cell subsets and VCS parameters were varied in different CHB syndrome types, suggesting that correlations exited a-mong T cell subsets, VCS parameters and syndrome type of CHB, which may provide useful information for Chinese medicine dialectical sub-typing of CHB.