中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2014年
30期
48-51
,共4页
丙泊酚%麻醉深度%应激反应%血流动力学
丙泊酚%痳醉深度%應激反應%血流動力學
병박분%마취심도%응격반응%혈류동역학
Propofol%Depth of anesthesia%Stress response%Hemodynamic
目的：探讨不同剂量丙泊酚对患儿麻醉深度、应激反应、血流动力学的影响。方法选择下腹部手术患儿60例的临床资料进行回顾性分析，根据丙泊酚的使用剂量分为3组。第1组21例，丙泊酚起始维持剂量10 mg/(kg·h)，后每隔20min减量2 mg/(kg·h)，以6 mg/(kg·h)维持到缝皮；第2组19例，丙泊酚初始维持剂量15 mg/(kg·h)，20 min后减量为10 mg/(kg·h)，40 min后减量为8 mg/(kg·h)维持到缝皮；第3组20例，丙泊酚初始维持剂量20 mg/(kg·h)，后每隔20 min减量5 mg/(kg·h)，以10 mg/(kg·h)维持到缝皮。评价3组患儿不同时间点BIS、血流动力学以及应激反应。结果第2组和第3组在各时间点麻醉深度大于第1组(P<0.01)。第3组对MAP和心率有明显的抑制作用。第1组的应激反应较第2组和第3组强(P<0.05)。结论丙泊酚用于儿童全麻按照15 mg/(kg·h)、10 mg/(kg·h)、8 mg/(kg·h)维持麻醉，患儿既可以达到较满意的麻醉深度，并且对应激反应和血流动力学的影响较轻。
目的：探討不同劑量丙泊酚對患兒痳醉深度、應激反應、血流動力學的影響。方法選擇下腹部手術患兒60例的臨床資料進行迴顧性分析，根據丙泊酚的使用劑量分為3組。第1組21例，丙泊酚起始維持劑量10 mg/(kg·h)，後每隔20min減量2 mg/(kg·h)，以6 mg/(kg·h)維持到縫皮；第2組19例，丙泊酚初始維持劑量15 mg/(kg·h)，20 min後減量為10 mg/(kg·h)，40 min後減量為8 mg/(kg·h)維持到縫皮；第3組20例，丙泊酚初始維持劑量20 mg/(kg·h)，後每隔20 min減量5 mg/(kg·h)，以10 mg/(kg·h)維持到縫皮。評價3組患兒不同時間點BIS、血流動力學以及應激反應。結果第2組和第3組在各時間點痳醉深度大于第1組(P<0.01)。第3組對MAP和心率有明顯的抑製作用。第1組的應激反應較第2組和第3組彊(P<0.05)。結論丙泊酚用于兒童全痳按照15 mg/(kg·h)、10 mg/(kg·h)、8 mg/(kg·h)維持痳醉，患兒既可以達到較滿意的痳醉深度，併且對應激反應和血流動力學的影響較輕。
목적：탐토불동제량병박분대환인마취심도、응격반응、혈류동역학적영향。방법선택하복부수술환인60례적림상자료진행회고성분석，근거병박분적사용제량분위3조。제1조21례，병박분기시유지제량10 mg/(kg·h)，후매격20min감량2 mg/(kg·h)，이6 mg/(kg·h)유지도봉피；제2조19례，병박분초시유지제량15 mg/(kg·h)，20 min후감량위10 mg/(kg·h)，40 min후감량위8 mg/(kg·h)유지도봉피；제3조20례，병박분초시유지제량20 mg/(kg·h)，후매격20 min감량5 mg/(kg·h)，이10 mg/(kg·h)유지도봉피。평개3조환인불동시간점BIS、혈류동역학이급응격반응。결과제2조화제3조재각시간점마취심도대우제1조(P<0.01)。제3조대MAP화심솔유명현적억제작용。제1조적응격반응교제2조화제3조강(P<0.05)。결론병박분용우인동전마안조15 mg/(kg·h)、10 mg/(kg·h)、8 mg/(kg·h)유지마취，환인기가이체도교만의적마취심도，병차대응격반응화혈류동역학적영향교경。
Objective To discuss effect of different doses of propofol for children anesthesia on depth, stress response and hemodynamic. Methods Clinical data of 60 cases with abdominal surgery were retrospectively analyzed. All cases were divided into 3 groups according to different doses of propofol. Group 1 of 21 cases, initial maintenance dose of propofol was 10 mg/(kg·h), then every 20 minutes reduced 2 mg/(kg·h), with 6 mg/(kg·h)maintaining to sew leather;Group 2 of 19 cases, initial maintenance dose of propofol was 15 mg/(kg·h)after 20 minutes reduced to 10 mg/(kg·h), after 40 minutes reduced to 8 mg/(kg·h)and maintained to sew leather; Group 3 of 20 cases, initial maintenance dose of propofol was 20 mg/(kg·h), then every 20 minutes reduced 5 mg/(kg·h), with 10 mg/(kg·h) maintaining to sew leather. BIS, hemodynamic and stress response of three groups in different time were compared. Results The depth of anesthesia of group 2 and group 3 at each time point were greater than in group 1(P<0.01). MAP and heart rate of group 3 were significantly inhibited. Stress response in group 1 was more intensity than group 2 and group 3 (P<0.05). Conclusion Propofol anesthesia for children with 15 mg/(kg·h), 10 mg/(kg·h), 8 mg/(kg·h) to maintain anesthesia, children can achieve satisfactory depth of anesthesia, and the impact on the stress response and hemodynamic are lighter.
