CAJ | 학술논문

目的：探讨腹水γ-干扰素(IFN-γ)、腺苷脱氨酶(ADA)在结核性腹膜炎诊治中的临床价值。方法分别检测29例结核腹膜炎患者、22例癌性腹水患者的腹水γ-干扰素、腺苷脱氨酶水平，并进行比较。结果结核性腹膜炎组中γ-干扰素、腺苷脱氨酶的水平及活性均高于癌性腹水组(P值均<0.05)。2项指标联合检测对结核性腹膜炎诊断的灵敏度为86.2%，特异度95.5%，与单独检测ADA比较，敏感度相近，其特异度明显增高。结论γ-干扰素、腺苷脱氨酶的检测对结核性和癌性腹腔积液的鉴别有临床意义，可用于两者的鉴别诊断，同时进行IFN-γ与ADA检测可提高结核性腹腔积液的诊断特异度。
목적：탐토복수γ-간우소(IFN-γ)、선감탈안매(ADA)재결핵성복막염진치중적림상개치。방법분별검측29례결핵복막염환자、22례암성복수환자적복수γ-간우소、선감탈안매수평，병진행비교。결과결핵성복막염조중γ-간우소、선감탈안매적수평급활성균고우암성복수조(P치균<0.05)。2항지표연합검측대결핵성복막염진단적령민도위86.2%，특이도95.5%，여단독검측ADA비교，민감도상근，기특이도명현증고。결론γ-간우소、선감탈안매적검측대결핵성화암성복강적액적감별유림상의의，가용우량자적감별진단，동시진행IFN-γ여ADA검측가제고결핵성복강적액적진단특이도。
Objective To discuss the clinic value of γ-IFN,ADA in diagnosis and treatment of tuberculous peritonitis. Methods The level of γ-IFN,ADA in pleural effusion of all the patients (29 cases of tuberculous peritonitis effulion and 22 cases of malignant ascites effusion) were detected and compared. Result The level and activity of tuberculous peritonitis group, interferon gamma, adenosine deaminase were higher in malignant ascites group (P<0.05).The combined detection of 2 indexes in the diagnosis of tuberculous peritonitis sensitivity was 86.2%, specificity 95.5%. Compared with the single detection of ADA, the sensitivity was similar, and the specificity increased. Conclusion Ascites effusion,γ-IFN and ADA all have the clinical significance on the identification between tuberculous peritonitis effusion and malignant ascites effusion, which can be used for differential diagnosis. At the same time, IFN-γand ADA examination can improve the diagnosis specificity of tuberculous pleural peritonitis.