CAJ | 학술논문

目的：观察瑞舒伐他汀对缺血性脑血管病患者颈动脉硬化的疗效。方法伴有颈动脉粥样硬化及血脂异常的缺血性脑血管病患者90例随机分为两组，常规组42例，给予常规药物治疗，瑞舒伐他汀组48例，在常规治疗基础上加瑞舒伐他汀治疗，疗程12周；比较两组治疗前后血清超敏C-反应蛋白(hs-CRP)、颈动脉内-中膜厚度(IMT)、颈动脉斑块数量及血脂的变化。结果常规组前后颈hs-CRP、动脉IMT、斑块数量以及血脂水平差异无统计学意义(P>0.05)；瑞舒伐他汀组治疗后hs-CRP、颈动脉IMT、斑块数量以及血脂水平显著降低(P<0.05)；与常规组治疗后比较，差异有统计学意义(P<0.05)。结论瑞舒伐他汀能显著降低缺血性脑血管病患者hs-CRP水平，延缓和逆转颈动脉粥样硬化，并可能预防脑血管病复发。
목적：관찰서서벌타정대결혈성뇌혈관병환자경동맥경화적료효。방법반유경동맥죽양경화급혈지이상적결혈성뇌혈관병환자90례수궤분위량조，상규조42례，급여상규약물치료，서서벌타정조48례，재상규치료기출상가서서벌타정치료，료정12주；비교량조치료전후혈청초민C-반응단백(hs-CRP)、경동맥내-중막후도(IMT)、경동맥반괴수량급혈지적변화。결과상규조전후경hs-CRP、동맥IMT、반괴수량이급혈지수평차이무통계학의의(P>0.05)；서서벌타정조치료후hs-CRP、경동맥IMT、반괴수량이급혈지수평현저강저(P<0.05)；여상규조치료후비교，차이유통계학의의(P<0.05)。결론서서벌타정능현저강저결혈성뇌혈관병환자hs-CRP수평，연완화역전경동맥죽양경화，병가능예방뇌혈관병복발。
Objective To observe the curative effect of rosuvastatin in the treatment of carotid artery atherosclerosis (CAA) of patients with ischemic cerebrovascular disease. Methods A total of 90 cases of ischemic cerebrovascular disease with CAA and dyslipidemia were randomly divided into two groups. Conventional group (n=42) received the conventional drug treatment for 12 weeks, and rosuvastatin group (n=48) received the rosuvastatin treatment in addition for 12 weeks. The changes of serum high sensitive C reactive protein (hs-CRP), carotid artery intima-media thickness (IMT), number of carotid plaques and the blood lipids before and after treatment were compared between the 2 groups. Results The changes of carotid artery IMT, number of carotid plaques and blood lipids had no significant difference in conventional group. The levels of hs-CRP, carotid artery IMT, number of carotid plaques and blood lipids were significantly decreased in the rosuvastatin group after treatment (P<0.05). Compared with the conventional group after treatment, the differences were statistically significant (P<0.05). Conclusion Rosuvastatin can effectively reduce the level of hs-CRP, while suspending and reversing the progression of CAA in patients with ischemic cerebrovascular diease. It may prevent the recurrence of cerebrovascular disease.