CAJ | 학술논문

目的：观察联用厄贝沙坦氨氯地平治疗原发性高血压的疗效、不良反应及对肾功能的影响。方法98例原发性高血压患者随机分为实验组(50例)和对照组(48例),实验组每日晨服厄贝沙坦150 mg,氨氯地平5 mg,对照组服氨氯地平10 mg,共12周。观察两组的血压、谷峰比值、尿微量白蛋白(mAlb)、尿β2-微球蛋白(β2-MG)、尿素氮(BUN)和血清肌酐(Scr)的变化。结果降压效果、谷峰比值差异无统计学意义(P>0.05)；mAlb、β2-MG：同组与治疗前比较及组间治疗后比较差异均有统计学意义(P<0.05),实验组降低明显(P<0.05)；BUN、Scr：治疗前后差异无统计学意义(P>0.05)。结论厄贝沙坦联合氨氯地平能平稳降压,逆转异常的血压昼夜节律,增加疗效,减少不良反应,降低mAlb、β2-MG,对原发性高血压肾损害早期有保护作用。
목적：관찰련용액패사탄안록지평치료원발성고혈압적료효、불량반응급대신공능적영향。방법98례원발성고혈압환자수궤분위실험조(50례)화대조조(48례),실험조매일신복액패사탄150 mg,안록지평5 mg,대조조복안록지평10 mg,공12주。관찰량조적혈압、곡봉비치、뇨미량백단백(mAlb)、뇨β2-미구단백(β2-MG)、뇨소담(BUN)화혈청기항(Scr)적변화。결과강압효과、곡봉비치차이무통계학의의(P>0.05)；mAlb、β2-MG：동조여치료전비교급조간치료후비교차이균유통계학의의(P<0.05),실험조강저명현(P<0.05)；BUN、Scr：치료전후차이무통계학의의(P>0.05)。결론액패사탄연합안록지평능평은강압,역전이상적혈압주야절률,증가료효,감소불량반응,강저mAlb、β2-MG,대원발성고혈압신손해조기유보호작용。
Objective To observe the curative effect and the adverse reactions of irbesartan combined with amlodipine in the treatment of primary hypertension and its influence on renal function. Methods A total of 92 cases of primary hypertension were randomly divided into experimental group (n=50) and control group (n=48). The experimental group took irbesartan 150 mg and amlodipine 5 mg every morning for 12 weeks, and the control group took amlodipine 10 mg every morning for 12 weeks. The changes of blood pressure, T/P ratio and urinary microalbumin (mAlb), urinary β2-microglobulin (β2-MG), blood urea nitrogen (BUN), and serum creatinine (Scr) were observed. Results There were no significant differnces of blood pressure and T/P ratio (P>0.05). The differences of mAlb、β2-MG were statistically significant for the same group before and after the treatment and between the two groups after the treatment (P<0.05), and the decrease of the experimental group was more obvious (P<0.05). The differences of BUN and Scr were not statistically significant before and after the treatment (P>0.05). Conclusion Irbesartan combined with amlodipine can steady lower blood pressure, correct abnormal circadian blood pressure, promote the curative effect, reduce the adverse reactions, lower mAlb andβ2-MG, and it has protective effect on early hypertensive renal disease.