CAJ | 학술논문

目的：探讨苯那普利与缬沙坦联合疗法对糖尿病肾病的临床效果。方法将74例糖尿病肾病患者随机分成两组，其中观察组39例、对照组35例，观察组采用苯那普利联合缬沙坦治疗，对照组仅采用苯那普利进行治疗，比较两组患者经20 w治疗后血糖、血压、24 h尿蛋白和血肌酐水平。结果两组患者治疗前后血糖、血压均明显下降，但两组治疗后比较差异无统计学意义，(>0.05)；观察组患者经治疗后24 h尿蛋白及血肌酐水平均明显低于治疗前(<0.05)，且观察组下降更为明显，两组治疗后比较差异显著(<0.05)。结论苯那普利联合缬沙坦较单用苯那普利治疗糖尿病肾病可有效降低患者血肌酐及蛋白尿水平，疗效更好，值得推广使用。
목적：탐토분나보리여힐사탄연합요법대당뇨병신병적림상효과。방법장74례당뇨병신병환자수궤분성량조，기중관찰조39례、대조조35례，관찰조채용분나보리연합힐사탄치료，대조조부채용분나보리진행치료，비교량조환자경20 w치료후혈당、혈압、24 h뇨단백화혈기항수평。결과량조환자치료전후혈당、혈압균명현하강，단량조치료후비교차이무통계학의의，(>0.05)；관찰조환자경치료후24 h뇨단백급혈기항수평균명현저우치료전(<0.05)，차관찰조하강경위명현，량조치료후비교차이현저(<0.05)。결론분나보리연합힐사탄교단용분나보리치료당뇨병신병가유효강저환자혈기항급단백뇨수평，료효경호，치득추엄사용。
Objective To study the benzene that captopril and valsartan the clinical ef ect of combined therapy for diabetic nephropathy. Methods 74 patients with diabetic nephropathy were randomly divided into two groups, one group 39 cases, control group 35 cases, observation group with benzene that captopril combined valsartan treatment, control group treated with benzene only the split, compared two groups of patients after treatment for 20 weeks 24 h urine protein and blood glucose, blood pressure, serum creatinine levels. Results Two groups of patients before and after treatment the blood sugar and blood pressure were significantly decreased, but there was no statistical y significant dif erence comparing the two groups after treatment, ( > 0.05);Observation group of patients after treatment of the 24 h urine protein and serum creatinine levels were significantly lower than before treatment ( < 0.05), and observation group decreased more obviously, the two groups after treatment was significant dif erence ( < 0.05). Conclusion Benzene that captopril combined valsartan than use benzene that captopril treatment of patients with diabetic nephropathy can ef ectively reduce serum creatinine and level of proteinuria, curative ef ect is bet er, worthy of promotion of use.