CAJ | 학술논문

目的：比较替硝唑不同用药方案治疗牙周炎的临床效果。方法选取我院2012-2013年收治的牙周炎患者60例，随机分为对照组和观察组，每组30例。两组患者均采用甲硝唑治疗，对照组口服给药，观察组局部给药，比较两组患者的临床疗效及治疗前后牙龈出血指数（ GI）、牙周袋探诊深度（ Pd）和菌斑指数（ PLI）。结果两组患者总有效率比较，差异无统计学意义（ P>0.05）。两组患者治疗前GI、Pd、PLI比较，差异无统计学意义（ P>0.05）；治疗后两组GI、Pd、PLI比较，差异无统计学意义（ P>0.05）。对照组不良反应发生率高于观察组，差异有统计学意义（ P<0.05）。结论替硝唑局部给药治疗牙周炎能有效减少不良反应发生率，且治疗效果与全身用药相当。
목적：비교체초서불동용약방안치료아주염적림상효과。방법선취아원2012-2013년수치적아주염환자60례，수궤분위대조조화관찰조，매조30례。량조환자균채용갑초서치료，대조조구복급약，관찰조국부급약，비교량조환자적림상료효급치료전후아간출혈지수（ GI）、아주대탐진심도（ Pd）화균반지수（ PLI）。결과량조환자총유효솔비교，차이무통계학의의（ P>0.05）。량조환자치료전GI、Pd、PLI비교，차이무통계학의의（ P>0.05）；치료후량조GI、Pd、PLI비교，차이무통계학의의（ P>0.05）。대조조불량반응발생솔고우관찰조，차이유통계학의의（ P<0.05）。결론체초서국부급약치료아주염능유효감소불량반응발생솔，차치료효과여전신용약상당。
Objective To compare the clinical effect of therapeutic regimens of tinidazole in treating of periodontitis. Methods A total of 60 patients with periodontitis admitted to our hospital from 2012 to 2013 were chosen,and they were ran-domly divided into control group and observation group,30 cases in each group. Both groups were treated with tinidazole,control group taken tinidazole orally and observation group taken tinidazole locally. Clinical effect between the two groups was compared, and gingival bleeding index( GI),pocket probing depth( Pd) and dental plaque index( PLI) of the two groups before and af-ter treatment observed. Results There was no significant differences of total effective rate between the two groups(P>0. 05). GI,Pd,PLI of two groups before treatment was not statistically significantly different(P>0. 05),but there was no significant differences of GI,Pd,PLI between the two groups afer treatment(P>0. 05). The incidence of adverse reactions of control group was higher than thatof observation group,the difference was statistically significant(P<0. 05). Conclusion Taking ti-nidazole locally can effectively reduce the incidence rate of adverse reaction and has similiar clinical effect in treating periodontitis compared with taking tinidazole orally.