中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
31期
4-5
,共2页
奥美拉唑%利培酮%9-羟利培酮%血药浓度%影响
奧美拉唑%利培酮%9-羥利培酮%血藥濃度%影響
오미랍서%리배동%9-간리배동%혈약농도%영향
Omeprazole%Risperidone%9-hydroxy risperidone%Blood drug concentration%Influence
目的：观察奥美拉唑对利培酮和9-羟利培酮血药浓度的影响。方法20例精神分裂症合并胃溃疡患者,给予利培酮联合奥美拉唑治疗1周。检测奥美拉唑治疗后利培酮以及9-羟利培酮血药浓度。结果未使用奥美拉唑前,利培酮与9-羟利培酮血药浓度为(29.25±7.82)μg/L；使用奥美拉唑后,利培酮与9-羟利培酮血药浓度为(37.15±11.68)μg/L,差异有统计学意义(P<0.05)。结论奥美拉唑能够提高利培酮与9-羟利培酮血药浓度,因此,临床上治疗精神分裂症合并胃溃疡患者,给予奥美拉唑联合利培酮治疗时,应该监测患者利培酮与9-羟利培酮血药浓度,及时对药物剂量进行调整。
目的：觀察奧美拉唑對利培酮和9-羥利培酮血藥濃度的影響。方法20例精神分裂癥閤併胃潰瘍患者,給予利培酮聯閤奧美拉唑治療1週。檢測奧美拉唑治療後利培酮以及9-羥利培酮血藥濃度。結果未使用奧美拉唑前,利培酮與9-羥利培酮血藥濃度為(29.25±7.82)μg/L；使用奧美拉唑後,利培酮與9-羥利培酮血藥濃度為(37.15±11.68)μg/L,差異有統計學意義(P<0.05)。結論奧美拉唑能夠提高利培酮與9-羥利培酮血藥濃度,因此,臨床上治療精神分裂癥閤併胃潰瘍患者,給予奧美拉唑聯閤利培酮治療時,應該鑑測患者利培酮與9-羥利培酮血藥濃度,及時對藥物劑量進行調整。
목적：관찰오미랍서대리배동화9-간리배동혈약농도적영향。방법20례정신분렬증합병위궤양환자,급여리배동연합오미랍서치료1주。검측오미랍서치료후리배동이급9-간리배동혈약농도。결과미사용오미랍서전,리배동여9-간리배동혈약농도위(29.25±7.82)μg/L；사용오미랍서후,리배동여9-간리배동혈약농도위(37.15±11.68)μg/L,차이유통계학의의(P<0.05)。결론오미랍서능구제고리배동여9-간리배동혈약농도,인차,림상상치료정신분렬증합병위궤양환자,급여오미랍서연합리배동치료시,응해감측환자리배동여9-간리배동혈약농도,급시대약물제량진행조정。
Objective To observe the influence of omeprazole on blood drug concentration of risperidone and 9-hydroxy risperidone. Methods A total of 20 schizophrenia with gastric ulcer cases were treated by risperidone combined with omeprazole for 1 week. Detections of blood drug concentration of risperidone and 9-hydroxy risperidone were made after the omeprazole treatment. Results Before application of omeprazole, blood drug concentration of risperidone and 9-hydroxy risperidone was (29.25±7.82)μg/L. After using omeprazole, blood drug concentration of risperidone and 9-hydroxy risperidone was (37.15±11.68) μg/L. The difference had statistical significance (P<0.05). Conclusion Omeprazole can increase the blood drug concentration of risperidone and 9-hydroxy risperidone, which should be monitored in the risperidone combined with omeprazole treatment of schizophrenia with gastric ulcer, and timely adjustment of drug dose is necessary.
