CAJ | 학술논문

目的：探讨老年高血压患者血栓前状态标志物和左室舒张功能的相关关系。方法选取2013年2月-2014年3月于青岛大学附属医院老年医学科就诊的原发性高血压患者204例，行组织多普勒超声心动图检查，并根据舒张早期左房室瓣环运动峰速度（ Em）/舒张晚期左房室瓣环运动峰速度（ Am）结果分为左室舒张功能减退组（LVDD）和左室舒张功能正常组（non - LVDD），分别检测两组患者的血浆纤维蛋白原（ FIB）、血管性血友病因子（vWF）、D -二聚体（D - D）、抗凝血酶原 III（AT - III）进行比较，并与组织多普勒检测的 Em、Em/ Am 进行相关性分析。结果 LVDD 组（n =133例）患者的 FIB、vWF、D - D 水平高于 non - LVDD 组（n =71例）（P <0.05）。Pear-son 相关分析显示：Em、Em/ Am 均与收缩压（SBP）、高血压史、FIB、vWF、D - D 呈负相关（ r 值分别为-0.232，-0.211；-0.217，-0.317；-0.489，-0.646；-0.444，-0.648；-0.174，-0.204；P 均<0.05）。多元线性回归分析显示：FIB、vWF、SBP 是影响老年高血压患者左室舒张功能的主要因素（标准回归系数=-0.493、-0.326、-0.118，P <0.05）。结论 FIB、vWF、SBP 是影响老年原发性高血压患者左室舒张功能减退的主要原因，并与左室舒张功能呈负相关关系。
목적：탐토노년고혈압환자혈전전상태표지물화좌실서장공능적상관관계。방법선취2013년2월-2014년3월우청도대학부속의원노년의학과취진적원발성고혈압환자204례，행조직다보륵초성심동도검사，병근거서장조기좌방실판배운동봉속도（ Em）/서장만기좌방실판배운동봉속도（ Am）결과분위좌실서장공능감퇴조（LVDD）화좌실서장공능정상조（non - LVDD），분별검측량조환자적혈장섬유단백원（ FIB）、혈관성혈우병인자（vWF）、D -이취체（D - D）、항응혈매원 III（AT - III）진행비교，병여조직다보륵검측적 Em、Em/ Am 진행상관성분석。결과 LVDD 조（n =133례）환자적 FIB、vWF、D - D 수평고우 non - LVDD 조（n =71례）（P <0.05）。Pear-son 상관분석현시：Em、Em/ Am 균여수축압（SBP）、고혈압사、FIB、vWF、D - D 정부상관（ r 치분별위-0.232，-0.211；-0.217，-0.317；-0.489，-0.646；-0.444，-0.648；-0.174，-0.204；P 균<0.05）。다원선성회귀분석현시：FIB、vWF、SBP 시영향노년고혈압환자좌실서장공능적주요인소（표준회귀계수=-0.493、-0.326、-0.118，P <0.05）。결론 FIB、vWF、SBP 시영향노년원발성고혈압환자좌실서장공능감퇴적주요원인，병여좌실서장공능정부상관관계。
Objective To investigate the relationship between the prothrombotic state markers and left - ventricular di-astolic function in aged hypertension patients. Methods A total of 204 essential hypertension patients in the affiliated hospital of Qingdao University who were in treatment from February,2013 to March,2014 was selected and conducted the tissue Doppler echocardiography inspection. According to the results of early diastolic mitral valve circumduction speed(Em)/ late diastolic mi-tral valve circumduction speed(Am),the patients were divided into LVDD group and non - LVDD group. Then we measured and compared the plasma levels of fibrinogen(FIB),von willebrand factor(vWF),D - dimer(D - D)and Antithrombin III (AT - III)of the two groups respectively,the results of which were made correlation analysis with Em and Em/ Am. Results The levels of FIB、D - D、vWF in LVDD(n = 133) group were obviously higher than those of non - LVDD group(n = 71) (P < 0. 05). Pearson correlation analysis showed that Em and Em/ Am were both negatively correlated with SBP,hypertension history,FIB,vWF and D - D( r = - 0. 232, - 0. 211; - 0. 217, - 0. 317; - 0. 489, - 0. 646; - 0. 444, - 0. 648;- 0. 174, - 0. 204;P < 0. 05 ). Multivariate liner regression analysis showed that FIB,vWF and SBP were the main risk fac-tors for left - ventricular diastolic function( Standard regression coefficient = - 0. 493, - 0. 326, - 0. 118;P < 0. 05). Con-clusion FIB,vWF and SBP are the main risk factors for left - ventricular diastolic function,and they are negatively correlated.