CAJ | 학술논문

目的探讨P16、Ki-67、Bcl-2抗体在宫颈上皮内瘤变(CIN)中的表达及应用价值。方法用快捷免疫组化染色法检测30例正常宫颈组织和66例CIN中p16、Ki-67和Bcl-2的表达，分析比较两组的标记结果。结果 CIN中p16、Ki-67、Bcl-2的阳性率显著高于正常宫颈(﹤0.05)，CINⅡ-Ⅲ的表达率显著高于CINⅠ(﹤0.05)。结论 P16、Ki-67和BCL-2抗体联合标记可作为病理诊断CIN和区分级别的重要参考指标。
목적탐토P16、Ki-67、Bcl-2항체재궁경상피내류변(CIN)중적표체급응용개치。방법용쾌첩면역조화염색법검측30례정상궁경조직화66례CIN중p16、Ki-67화Bcl-2적표체，분석비교량조적표기결과。결과 CIN중p16、Ki-67、Bcl-2적양성솔현저고우정상궁경(﹤0.05)，CINⅡ-Ⅲ적표체솔현저고우CINⅠ(﹤0.05)。결론 P16、Ki-67화BCL-2항체연합표기가작위병리진단CIN화구분급별적중요삼고지표。
Objective To investigate the expressions and clinic significance of p16,Ki-67 and Bcl-2 in the diagnosis and therapy of cervical intraepithelial neoplasia (CIN).Methods The pathological tissue microar ay,involved 30 cases of normal cervix epitheliums and 66 cases of cervical intraepithelial neoplasia,was used to detect expressions of p16, Ki-67 and Bcl-2 in the tissues with immunohistochemistry and then to analyse the significance of dif erence of expressions in those cases respectively.Results The positive rates of expressions of p16, Ki-67 and Bcl-2 in CIN were significantely higher than those in normal cervix ( <0.05). Also, positive rates of expressions of al markers in CIN II-I I were significantly higher than those in CIN I ( <0.05).Conclusion In clinical pathology,It is useful and significant in diagnosis and staging of CIN to combine p16,Ki-67 and Bcl-2 as antibody-markers.