医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
31期
27-27
,共1页
口服避孕药%体外受精-胚胎移植%超促排卵%多囊卵巢综合征
口服避孕藥%體外受精-胚胎移植%超促排卵%多囊卵巢綜閤徵
구복피잉약%체외수정-배태이식%초촉배란%다낭란소종합정
Oral contraceptive pil%IVF-ET%Control ed ovarian hyperstimulation%Polycystic ovarian syndrome
目的研究体外受精-胚胎移植(IVF-ET)中多囊卵巢综合征(Polycystic ovarian syndrome,PCOS)患者在超促排卵周期前应用口服避孕药(OCP,oral contraceptive pil )预处理的效果。方法回顾性分析100例行IVF-ET的多囊卵巢综合征患者，按周期前是否使用过OCP分为A组(OCP预处理组，55例)和B组(对照组，45例)。对入选患者的病历资料进行统计分析，评估口服避孕药预处理对多囊卵巢综合征患者促排卵的效果、中重度卵巢过度刺激综合征(OHSS,ovarian hyperstimulation syndrome)的发生及助孕结果的影响。结果OCP预处理能明显减少卵巢功能性囊肿形成(<0.05)，OCP预处理组的Gn(gonadotropin,促性腺激素)用药天数和剂量均比对照组增加(<0.01)，而成熟卵率更高，中重度OHSS发生率低于对照组，但差异无显著性(>0.05)，两组获卵数、受精率、流产率、临床妊娠率等差异均无统计学意义。结论 OCP预处理能较好地控制多囊卵巢综合征患者促排卵的时间，卵泡发育同步性更高，但并不改变中重度OHSS的发生率，Gn天数与Gn剂量较对照组增加。
目的研究體外受精-胚胎移植(IVF-ET)中多囊卵巢綜閤徵(Polycystic ovarian syndrome,PCOS)患者在超促排卵週期前應用口服避孕藥(OCP,oral contraceptive pil )預處理的效果。方法迴顧性分析100例行IVF-ET的多囊卵巢綜閤徵患者，按週期前是否使用過OCP分為A組(OCP預處理組，55例)和B組(對照組，45例)。對入選患者的病歷資料進行統計分析，評估口服避孕藥預處理對多囊卵巢綜閤徵患者促排卵的效果、中重度卵巢過度刺激綜閤徵(OHSS,ovarian hyperstimulation syndrome)的髮生及助孕結果的影響。結果OCP預處理能明顯減少卵巢功能性囊腫形成(<0.05)，OCP預處理組的Gn(gonadotropin,促性腺激素)用藥天數和劑量均比對照組增加(<0.01)，而成熟卵率更高，中重度OHSS髮生率低于對照組，但差異無顯著性(>0.05)，兩組穫卵數、受精率、流產率、臨床妊娠率等差異均無統計學意義。結論 OCP預處理能較好地控製多囊卵巢綜閤徵患者促排卵的時間，卵泡髮育同步性更高，但併不改變中重度OHSS的髮生率，Gn天數與Gn劑量較對照組增加。
목적연구체외수정-배태이식(IVF-ET)중다낭란소종합정(Polycystic ovarian syndrome,PCOS)환자재초촉배란주기전응용구복피잉약(OCP,oral contraceptive pil )예처리적효과。방법회고성분석100례행IVF-ET적다낭란소종합정환자，안주기전시부사용과OCP분위A조(OCP예처리조，55례)화B조(대조조，45례)。대입선환자적병력자료진행통계분석，평고구복피잉약예처리대다낭란소종합정환자촉배란적효과、중중도란소과도자격종합정(OHSS,ovarian hyperstimulation syndrome)적발생급조잉결과적영향。결과OCP예처리능명현감소란소공능성낭종형성(<0.05)，OCP예처리조적Gn(gonadotropin,촉성선격소)용약천수화제량균비대조조증가(<0.01)，이성숙란솔경고，중중도OHSS발생솔저우대조조，단차이무현저성(>0.05)，량조획란수、수정솔、유산솔、림상임신솔등차이균무통계학의의。결론 OCP예처리능교호지공제다낭란소종합정환자촉배란적시간，란포발육동보성경고，단병불개변중중도OHSS적발생솔，Gn천수여Gn제량교대조조증가。
Objective To investigate the ef ects of oral contraceptive pil (OCP)pretreatment in patients with polycystic ovarian syndrome (PCOS)undergoing control ed ovarian hyperstimulation(COS)for IVF-ET(in vitro fertilization and embryo transfer).Methods 100patients with PCOS undergoing IVF-ET were randomized divided into group A(n=55),who received OCP pretreatment before cycle and group B (n=45),who did not received OCP.A retrospective analysis of the data of the patients was car ied out for the assessment of the ovulation promoting ef ect of OCP pretreatment and the influence on the incidence of OHSS and IVF-ET results.Results The formation of ovarian cyst was significantly decreased in group A ( <0.01).Compared with group B,the duration of gonadotropin stimulation and the gonadotropin consumption were both increased in group A ( <0.05).The ratio of ovium was increased in group A (92.85%versus 87.92%, <0.05).But no significant dif erences were observed regarding on the proportion of patients who developed OHSS,the number of retrieved oocytes,fertilization rate,miscar iagerate and clinical pregnancy rate.Conclusion OCP pretreatment in patients with PCOS could help the doctor to control the time of ovarian stimulation ef ectively.It may improve the synchronism of fol icular development,though the duration of gonadotropin stimulation and the gonadotropin consumption were significantly increased in OCP pretreatment group.OCP pretreatment did not change the incidence of OHSS of medium degree or above.
