CAJ | 학술논문

乳腺癌是严重威胁世界女性健康的常见恶性肿瘤之一，近年研究发现，基因组不稳定性是肿瘤发生发展的重要分子机制，与肿瘤预后差及多重耐药相关。通过对乳腺癌相关基因改变的研究，寻找与乳腺癌发生相关的不稳定基因，探索其与乳腺癌发生发展的机制，是当前乳腺癌基因领域的一个重要研究方向，同时能够为个体化治疗提供新的靶点。本文主要就与乳腺癌基因组不稳定性相关的基因、形成机制以及临床应用方面的研究成果进行综述。
유선암시엄중위협세계녀성건강적상견악성종류지일，근년연구발현，기인조불은정성시종류발생발전적중요분자궤제，여종류예후차급다중내약상관。통과대유선암상관기인개변적연구，심조여유선암발생상관적불은정기인，탐색기여유선암발생발전적궤제，시당전유선암기인영역적일개중요연구방향，동시능구위개체화치료제공신적파점。본문주요취여유선암기인조불은정성상관적기인、형성궤제이급림상응용방면적연구성과진행종술。
Breast cancer(BC)is one of the commonest malignancy threatening women's health in the world. Recent studies have showed that genomic stability is a major molecular mechanism in the occurrence and development of cancers,which is related to poor prognoses and multi - drug resistance. It is an important research orientation to find the unstable genes associat-ed with BC occurrence and to explore its mechanisms through the research on BC related gene changes,which can provide new targets for individualized treatments. This paper reviews the recent achievements in researches on genes related to BC genomic in-stability and its formation mechanism and clinical application.