CAJ | 학술논문

目的：系统评价烧伤皮肤再生医疗技术〔湿润暴露疗法/湿润烧伤膏（MEBT/ MEBO）〕治疗糖尿病足部溃疡的疗效和安全性。方法计算机检索 Medline、EMBase、Cochrane 图书馆临床试验资料库、中国生物医学文献数据库、中国知网、维普数据库和万方数字化期刊群，并手工检索相关领域其他杂志，检索时间为数据库创建至2014年4月。纳入以糖尿病足患者为研究对象、比较 MEBT/ MEBO 与其他创面治疗方法的随机对照试验（RCT）。评价纳入文献的质量，采用 RevMan 5.1软件进行系统评价。结果共纳入10篇 RCT，包括668例患者。纳入文献中1篇文献质量为 A 级，8篇文献为 B 级，1篇文献为 C 级。系统评价结果显示：采用 MEBT/ MEBO 为主处理创面的疗效优于对照组〔OR =3.94，95% CI（2.30，6.77），P <0.00001〕，亚组分析亦支持上述结果，且未发现治疗不良反应。结论基于目前的研究，MEBT/ MEBO 治疗糖尿病足疗效肯定，无不良反应，是临床糖尿病足的有效治疗方法之一。
목적：계통평개소상피부재생의료기술〔습윤폭로요법/습윤소상고（MEBT/ MEBO）〕치료당뇨병족부궤양적료효화안전성。방법계산궤검색 Medline、EMBase、Cochrane 도서관림상시험자료고、중국생물의학문헌수거고、중국지망、유보수거고화만방수자화기간군，병수공검색상관영역기타잡지，검색시간위수거고창건지2014년4월。납입이당뇨병족환자위연구대상、비교 MEBT/ MEBO 여기타창면치료방법적수궤대조시험（RCT）。평개납입문헌적질량，채용 RevMan 5.1연건진행계통평개。결과공납입10편 RCT，포괄668례환자。납입문헌중1편문헌질량위 A 급，8편문헌위 B 급，1편문헌위 C 급。계통평개결과현시：채용 MEBT/ MEBO 위주처리창면적료효우우대조조〔OR =3.94，95% CI（2.30，6.77），P <0.00001〕，아조분석역지지상술결과，차미발현치료불량반응。결론기우목전적연구，MEBT/ MEBO 치료당뇨병족료효긍정，무불량반응，시림상당뇨병족적유효치료방법지일。
Objective To review systematically the efficacy and safety of moist exposed burn therapy(MEBT) / moist exposed burn ointment(MEBO)for diabetic foot ulcer. Methods Medline,EMBase,Cochrane Library,CBM,CNKI,VIP and Wanfang(WF)database were searched for randomized controlled trials(RCT) of MEBT/ MEBO for diabetic foot ulcers and read some related journals as well. The quality of the enrolled literatures were evaluated and used RevMan 5. 1 software to perform systematic review. Results A total of 10 literatures of RCT including 668 patients. One of the literatures was A - level, 8 were B - level,1 was C - level. By systematic review showed that the effect of MEBT/ MEBO on wound surface was superior to that of control group〔OR = 3. 94,95% CI(2. 30,6. 77),P < 0. 000 01〕. And subgroup analysis supported the above results without any adverse reactions. Conclusion MEBT/ MEBO,more effective and safer than other treatments for diabetic foot,is one of the effective methods in clinical treatment of diabetic foot.