CAJ | 학술논문

目的：探讨蒲地蓝消炎口服液佐治复发性口腔溃疡（ ROU）及糜烂型口腔扁平苔藓（ eOLP）的短期疗效。方法选取2013年5-10月在中国医科大学附属盛京医院口腔科就诊的口腔黏膜疾病患者150例，其中 ROU 患者96例，eOLP 患者54例。分别将 ROU 患者及 eOLP 患者采用随机数字表法分为试验组、对照组1和对照组2。试验组采用局部外用喷剂联合中成药蒲地蓝消炎口服液含服，对照组1单纯使用西药局部治疗，对照组2单纯使用蒲地蓝消炎口服液含服，各组用药为期2周。分别在用药后第1周和用药后第2周对3组疗效〔观察患者视觉模拟评分、病变范围（糜烂或溃疡直径变化）、黏膜充血程度等〕进行评价。结果 ROU 患者中试验组50例、对照组1和对照组2各23例；eOLP 患者中试验组30例、对照组1和对照组2各12例。不同口腔疾病类型下3组患者的民族、性别、年龄、病程、视觉模拟评分、充血程度分布情况、最大直径比较，差异均无统计学意义（ P >0.05）。用药后第1周， ROU、eOLP 患者3组总有效率比较，差异有统计学意义（P <0.05）；且 ROU、eOLP 患者试验组总有效率高于对照组1和对照组2（P <0.01）。用药后第2周，ROU 患者3组总有效率比较，差异无统计学意义（P >0.05）；eOLP 患者3组总有效率比较，差异有统计学意义（P <0.05），且试验组总有效率高于对照组1（P <0.01）。试验中未出现明显不良反应而停药及不良黏膜着色现象。结论采用蒲地蓝佐治 ROU 及 eOLP 短期效果显著，能明显提高患者总有效率，缓解症状，且无不良反应发生，值得临床参考应用。
목적：탐토포지람소염구복액좌치복발성구강궤양（ ROU）급미란형구강편평태선（ eOLP）적단기료효。방법선취2013년5-10월재중국의과대학부속성경의원구강과취진적구강점막질병환자150례，기중 ROU 환자96례，eOLP 환자54례。분별장 ROU 환자급 eOLP 환자채용수궤수자표법분위시험조、대조조1화대조조2。시험조채용국부외용분제연합중성약포지람소염구복액함복，대조조1단순사용서약국부치료，대조조2단순사용포지람소염구복액함복，각조용약위기2주。분별재용약후제1주화용약후제2주대3조료효〔관찰환자시각모의평분、병변범위（미란혹궤양직경변화）、점막충혈정도등〕진행평개。결과 ROU 환자중시험조50례、대조조1화대조조2각23례；eOLP 환자중시험조30례、대조조1화대조조2각12례。불동구강질병류형하3조환자적민족、성별、년령、병정、시각모의평분、충혈정도분포정황、최대직경비교，차이균무통계학의의（ P >0.05）。용약후제1주， ROU、eOLP 환자3조총유효솔비교，차이유통계학의의（P <0.05）；차 ROU、eOLP 환자시험조총유효솔고우대조조1화대조조2（P <0.01）。용약후제2주，ROU 환자3조총유효솔비교，차이무통계학의의（P >0.05）；eOLP 환자3조총유효솔비교，차이유통계학의의（P <0.05），차시험조총유효솔고우대조조1（P <0.01）。시험중미출현명현불량반응이정약급불량점막착색현상。결론채용포지람좌치 ROU 급 eOLP 단기효과현저，능명현제고환자총유효솔，완해증상，차무불량반응발생，치득림상삼고응용。
Objective To investigate the short - term clinical effect of Pudilan as an adjunctive therapy in the treat-ment of recurrent oral ulcer(ROU)and erosive oral lichen planus(eOLP). Methods A total of 150 patients with oral mucosal diseases,including 96 cases of ROU and 54 cases of eOLP admitted to Shengjing Hospital of China Medical University from May to October in 2013 were selected. All the patients were randomly divided into experiment group,control group 1 and control group 2. The experiment group was treated with topical spray combined with Pudilan,and the control group 1 was treated with only topi-cal spray and the control group 2 was treated with only Pudilan. All the groups were treated for two weeks. The clinical effect (pain degree,extent of disease,including erosion and ulcer level,diameter and changes of white stripes,congestion)of the three groups was evaluated one week and two weeks after treatment. Results There were 50 cases,23 cases and 23 cases of ROU in the experiment group,control group 1 and control group 2 respectively,and there were 30 cases,12 cases and 12 cases of eOLP in the experiment group,control group 1 and control group 2 respectively. The nationality,sex,age,course of dis-ease,VAS,congestion and maximum diameter of the two types of diseases showed no statistically significant difference( P >0. 05). The overall response rate of the three groups of ROU and the three groups of eOLP showed statistically significant differ-ences one week after treatment(P < 0. 05). The overall response rate of the experiment groups of ROU and eOLP was signifi-cantly higher than the control group 1 and control group 2 one week after treatment(P < 0. 01). Two weeks after treatment,the overall response rate of the three groups of ROU showed no statistically significant difference(P > 0. 05),while the overall re-sponse rate of the three groups of eOLP showed statistically significant differences(P < 0. 05),with the overall response rate of the experiment group higher than the control group 1(P < 0. 01). No adverse reaction and mucosa staining appeared during the experiment. Conclusion Pudilan as an adjunctive therapy has an obvious short - term effect. It can improve the overall response rate and shorten the duration of treatment,and it can also relieve symptoms and reduce the incidence of adverse reactions,so it should be promoted in clinic.