CAJ | 학술논문

目的：通过检测孕妇早期血清中解整合素-金属蛋白酶12-S（a disintegrin and metalloprotease 12，ADAM12-S）水平及变化趋势，探讨解整合素-金属蛋白酶12-S在孕妇早期异位妊娠诊断中的价值。方法选取黄冈市妇幼保健院就诊的早孕期妇女（孕5～10周）150例，其中正常妊娠102例，异位妊娠48例，留取其血清，利用时间分辨荧光免疫分析法检测血清中解整合素-金属蛋白酶12-S值。结果102例正常妊娠组孕妇血清中ADAM12-S 值随孕周呈线性稳定增长，相关系数r＝0.9217（P＜0.05）；48例异位妊娠组孕妇血清中ADAM12-S值明显低于正常妊娠组且随孕周未呈线性稳定增长，相关系数r＝0.2817；异位妊娠组各孕周的中位数倍数明显低于正常对照组，差异有统计学意义（P＜0.05）。结论 ADAM12-S 在早孕正常妊娠中数值稳定，而在异常妊娠中数值低，在孕妇早期异位妊娠诊断中具有重要价值。
목적：통과검측잉부조기혈청중해정합소-금속단백매12-S（a disintegrin and metalloprotease 12，ADAM12-S）수평급변화추세，탐토해정합소-금속단백매12-S재잉부조기이위임신진단중적개치。방법선취황강시부유보건원취진적조잉기부녀（잉5～10주）150례，기중정상임신102례，이위임신48례，류취기혈청，이용시간분변형광면역분석법검측혈청중해정합소-금속단백매12-S치。결과102례정상임신조잉부혈청중ADAM12-S 치수잉주정선성은정증장，상관계수r＝0.9217（P＜0.05）；48례이위임신조잉부혈청중ADAM12-S치명현저우정상임신조차수잉주미정선성은정증장，상관계수r＝0.2817；이위임신조각잉주적중위수배수명현저우정상대조조，차이유통계학의의（P＜0.05）。결론 ADAM12-S 재조잉정상임신중수치은정，이재이상임신중수치저，재잉부조기이위임신진단중구유중요개치。
Objective To determine the values and variation tendency of a disintegrin and metalloprotease 12-S(ADAM12-S)of early pregnancy, and discuss the value of ADAM12-S to the ectopic pregnancy in the first trimester.Methods 150 early pregnancy cases (from the 5th to 10th week of pregnancy)were selected in Huanggang Women &Children's Healthcare Hospital.There were 102 cases of normal pregnancy,48 cases of ectopic pregnancy.The AutoDELFIA immunoassay platform was used to measure the value of ADAM12-S in the serum.Results Of the 102 normal pregnancies, the values of ADAM12-S in 5th-10th week of pregnancy linearly increase with gestationalage.The correlation coefficient was 0.9217 (P<0.05).While the values of ADAM12-S in the ectopic pregnancy group were significantly lower than the normal pregnancy group and not linearly increased with gestationalage.The correlation coefficient was 0.2817.There was statistically significant difference between the two groups (P<0.05).Conclusion The values of ADAM12-S is stable in the first trimester of normal pregnancy,while it is much more lower in abnormal pregnancy.ADAM12-S has great significance in the diagnosis of ectopic pregnancy of the first trimester.