北京口腔医学
北京口腔醫學
북경구강의학
BEIJING JOURNAL OF STOMATOLOGY
2014年
5期
276-280
,共5页
付茜%肖江%林端娴%梁宏远%赵红心
付茜%肖江%林耑嫻%樑宏遠%趙紅心
부천%초강%림단한%량굉원%조홍심
艾滋病%人获得性免疫缺陷病毒%高效抗逆转病毒治疗%口腔病损%CD4计数
艾滋病%人穫得性免疫缺陷病毒%高效抗逆轉病毒治療%口腔病損%CD4計數
애자병%인획득성면역결함병독%고효항역전병독치료%구강병손%CD4계수
AIDS%HIV%HAART%Oral lesions%CD4 lymphocytes
目的：了解艾滋病相关口腔病损的临床特点及其与CD4计数和高效抗逆转病毒治疗( highly active antiretroviral therapy,HAART)之间的关系。方法回顾性研究2012~2013年在我院收治的109例HIV/AIDS患者的临床资料,包括流行病史、艾滋病临床阶段、口腔表现、全身症状、CD4计数、治疗及预后等,通过Excel建立数据库,进行统计学分析。结果109例HIV/AIDS患者中48例出现艾滋病相关口腔病损,其中口腔念珠菌感染48例(44．03%),以假膜型为主,口腔深大溃疡5例(4．59%),卡波西肉瘤和淋巴瘤各2例(1．83%),牙龈线型红斑、口腔单纯疱疹和口腔疣各1例(0．92%)。 CD4<200个/ul组口腔病损的发生率高于CD4≧200个/ul(P<0．01), HAART治疗组口腔病损的发生率低于未治疗组(P<0．01),差异有显著性。结论口腔是HIV/AIDS患者最常见的机会性感染部位。口腔病损中以假膜型口腔念珠菌病最常见,其次是口腔深大溃疡、口腔恶性肿瘤。卡波西肉瘤和淋巴瘤死亡率高,早期口腔表现易与淋巴结炎、牙龈炎混淆,应尽早进行病理检查,早期诊断。 HIV/AIDS患者口腔病损的发生与CD4计数减少有关,HAART治疗能显著降低口腔病损的发生。
目的：瞭解艾滋病相關口腔病損的臨床特點及其與CD4計數和高效抗逆轉病毒治療( highly active antiretroviral therapy,HAART)之間的關繫。方法迴顧性研究2012~2013年在我院收治的109例HIV/AIDS患者的臨床資料,包括流行病史、艾滋病臨床階段、口腔錶現、全身癥狀、CD4計數、治療及預後等,通過Excel建立數據庫,進行統計學分析。結果109例HIV/AIDS患者中48例齣現艾滋病相關口腔病損,其中口腔唸珠菌感染48例(44．03%),以假膜型為主,口腔深大潰瘍5例(4．59%),卡波西肉瘤和淋巴瘤各2例(1．83%),牙齦線型紅斑、口腔單純皰疹和口腔疣各1例(0．92%)。 CD4<200箇/ul組口腔病損的髮生率高于CD4≧200箇/ul(P<0．01), HAART治療組口腔病損的髮生率低于未治療組(P<0．01),差異有顯著性。結論口腔是HIV/AIDS患者最常見的機會性感染部位。口腔病損中以假膜型口腔唸珠菌病最常見,其次是口腔深大潰瘍、口腔噁性腫瘤。卡波西肉瘤和淋巴瘤死亡率高,早期口腔錶現易與淋巴結炎、牙齦炎混淆,應儘早進行病理檢查,早期診斷。 HIV/AIDS患者口腔病損的髮生與CD4計數減少有關,HAART治療能顯著降低口腔病損的髮生。
목적：료해애자병상관구강병손적림상특점급기여CD4계수화고효항역전병독치료( highly active antiretroviral therapy,HAART)지간적관계。방법회고성연구2012~2013년재아원수치적109례HIV/AIDS환자적림상자료,포괄류행병사、애자병림상계단、구강표현、전신증상、CD4계수、치료급예후등,통과Excel건립수거고,진행통계학분석。결과109례HIV/AIDS환자중48례출현애자병상관구강병손,기중구강념주균감염48례(44．03%),이가막형위주,구강심대궤양5례(4．59%),잡파서육류화림파류각2례(1．83%),아간선형홍반、구강단순포진화구강우각1례(0．92%)。 CD4<200개/ul조구강병손적발생솔고우CD4≧200개/ul(P<0．01), HAART치료조구강병손적발생솔저우미치료조(P<0．01),차이유현저성。결론구강시HIV/AIDS환자최상견적궤회성감염부위。구강병손중이가막형구강념주균병최상견,기차시구강심대궤양、구강악성종류。잡파서육류화림파류사망솔고,조기구강표현역여림파결염、아간염혼효,응진조진행병리검사,조기진단。 HIV/AIDS환자구강병손적발생여CD4계수감소유관,HAART치료능현저강저구강병손적발생。
Objective To evaluate the clinical characteristics of oral lesions in HIV/AIDS patients and its relationship with CD4 and highly active antiretroviral therapy(HAART). Methods The clinical data of 109 HIV/AIDS in-patients in Ditan Hospital were reviewed, including epidemic data, clinical stages of HIV infection, oral manifestations, CD4 cell counts and prognosis. Results A total of 48 cases (44. 04%) of AIDS-associated oral lesions were found in 109 HIV/AIDS patients, in which oral candidiasis (43 cases, 39. 45%), especially pseudomembranous one, was the most common oral lesion, followed by severe oral ulcer (5 cases, 4. 59%), Kaposi’s sarcoma and lymphoma (2 cases, 1. 83%, respectively), the gum line erythema, oral simplex herpes and oral warts (1 case, respectively). The prevalence of oral lesions in CD4<200 cells/ul group was higher than that in CD4≧200 cells/ul group(P<0. 01), and the incidence of oral lesions in HAART group was lower than that in untreated group(P<0. 01). Conclusion Oral cavity was the most common site for most opportunistic infection. Pseudomembranous oral Candidiasis was the most common oral lesion, followed by severe oral ulcer and oral malignant neoplasm. Oral lesions in HIV/AIDS patients were associated with lower CD4 cells counts, and HAART medications can significantly reduce prevalence of AIDS-associated oral lesions.
