中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
7期
114-116,119
,共4页
前列腺癌%直肠超声%血清前列腺特异性抗原(PSA)%logistic回归模型
前列腺癌%直腸超聲%血清前列腺特異性抗原(PSA)%logistic迴歸模型
전렬선암%직장초성%혈청전렬선특이성항원(PSA)%logistic회귀모형
prostate cancer%transrectal ultrasound%prostatespecific antigen(PSA)%logistic regression model
目的：探讨logistic回归模型的相关参数（患者年龄及直肠超声特征联合血清PSA水平）对前列腺癌的预测价值分析。方法选取2011年1月～2014年1月聊城市人民医院收治的424例前列腺疾病患者的临床资料进行回顾性分析，对患者的年龄及直肠超声检查结果与穿刺病理检查结果进行统计分析，并建立logistic回归模型。结果在前列腺癌患者分年龄段比较中，70岁以上的患者的PSA水平明显高于其他年龄段的患者（P＜0.05）；前列腺癌患者与非癌性前列腺疾病患者在各个PSA水平的比较中差异均有统计学意义（P＜0.05）；2组患者的前列腺形状、前列腺边界、内外腺边界、前列腺和精囊腺分离线的清晰度、前列腺和直肠分离线清晰度、淋巴结转移、非正常血流信号及弱回声之间的比较差异均有统计学意义（P＜0.05），而结节和不均匀回声2个因素的比较差异无统计学意义；经直肠超声声像图联合年龄及PSA诊断前列腺癌的准确度为83.46％，特异性为92.73％，敏感度为65.01％，阳性预测值为81.89％，阴性预测值为83.95％。结论 logistic回归模型的相关参数如患者年龄及直肠超声特征联合血清PSA水平对前列腺癌的预测结果较佳。
目的：探討logistic迴歸模型的相關參數（患者年齡及直腸超聲特徵聯閤血清PSA水平）對前列腺癌的預測價值分析。方法選取2011年1月～2014年1月聊城市人民醫院收治的424例前列腺疾病患者的臨床資料進行迴顧性分析，對患者的年齡及直腸超聲檢查結果與穿刺病理檢查結果進行統計分析，併建立logistic迴歸模型。結果在前列腺癌患者分年齡段比較中，70歲以上的患者的PSA水平明顯高于其他年齡段的患者（P＜0.05）；前列腺癌患者與非癌性前列腺疾病患者在各箇PSA水平的比較中差異均有統計學意義（P＜0.05）；2組患者的前列腺形狀、前列腺邊界、內外腺邊界、前列腺和精囊腺分離線的清晰度、前列腺和直腸分離線清晰度、淋巴結轉移、非正常血流信號及弱迴聲之間的比較差異均有統計學意義（P＜0.05），而結節和不均勻迴聲2箇因素的比較差異無統計學意義；經直腸超聲聲像圖聯閤年齡及PSA診斷前列腺癌的準確度為83.46％，特異性為92.73％，敏感度為65.01％，暘性預測值為81.89％，陰性預測值為83.95％。結論 logistic迴歸模型的相關參數如患者年齡及直腸超聲特徵聯閤血清PSA水平對前列腺癌的預測結果較佳。
목적：탐토logistic회귀모형적상관삼수（환자년령급직장초성특정연합혈청PSA수평）대전렬선암적예측개치분석。방법선취2011년1월～2014년1월료성시인민의원수치적424례전렬선질병환자적림상자료진행회고성분석，대환자적년령급직장초성검사결과여천자병리검사결과진행통계분석，병건립logistic회귀모형。결과재전렬선암환자분년령단비교중，70세이상적환자적PSA수평명현고우기타년령단적환자（P＜0.05）；전렬선암환자여비암성전렬선질병환자재각개PSA수평적비교중차이균유통계학의의（P＜0.05）；2조환자적전렬선형상、전렬선변계、내외선변계、전렬선화정낭선분리선적청석도、전렬선화직장분리선청석도、림파결전이、비정상혈류신호급약회성지간적비교차이균유통계학의의（P＜0.05），이결절화불균균회성2개인소적비교차이무통계학의의；경직장초성성상도연합년령급PSA진단전렬선암적준학도위83.46％，특이성위92.73％，민감도위65.01％，양성예측치위81.89％，음성예측치위83.95％。결론 logistic회귀모형적상관삼수여환자년령급직장초성특정연합혈청PSA수평대전렬선암적예측결과교가。
Objective To construct a logistic regression model about the patients' age and transrectal ultrasound characteristics combined with serum PSA level and to predict prostate cancer.Methods 424 clinical data of patients with prostate disease in our hospital from January 2011 to January 2014 were retrospectively analyzed,the patients' age ,transrectal ultrasound pathological findings and biopsy findings in patients were used to establish a logistic regression model.Results Compared to patients with prostate cancer by age segment,>70 years of age or PSA levels in patients was significantly higher than in patients with other age groups;prostate cancer patients and patients with non-cancerous prostate disease were significant differences in the comparison of the various PSA levels (P<0.05);shape of two groups of patients with prostate,prostate boundaries,both inside and outside the boundaries gland,prostate and seminal vesicles separation line clarity,prostate and rectum separation line definition,lymph node metastasis, abnormal blood flow signals and weak echo comparison with a statistically significant difference between two groups(P<0.05 ),whereas no significant difference between nodules and uneven echo two factors (P>0.05 );transrectal ultrasonographic combined age and PSA prostate cancer diagnosis sensitivity of 65.01% and a specificity of 92.73% and accuracy was 83.46%,81.89% positive predictive value,negative predictive value 83.95%. Conclusion Age and characteristics of patients with rectal ultrasound combined with serum PSA level logistic regression model to predict the results of the prostate is better,and should be introduced.
