中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
7期
90-92
,共3页
王雪丹%王培培%张勇%韩艳珍
王雪丹%王培培%張勇%韓豔珍
왕설단%왕배배%장용%한염진
盐酸小檗碱%急性脑梗死%HIF-1α%Caspase-3
鹽痠小檗堿%急性腦梗死%HIF-1α%Caspase-3
염산소벽감%급성뇌경사%HIF-1α%Caspase-3
berberine hydrochloride%acute cerebral infarction%HIF-1α%Caspase-3
目的：通过多中心研究，探究盐酸小檗碱对急性脑梗死患者血清中HIF-1α、Caspase-3水平的影响。方法选取2012年1月～2014年1月河北工程大学附属医院、邯郸市第一医院、邯郸市中心医院神经内科收治的急性脑梗死患者共126例，采用随机数字表分为实验组和对照组。对照组63例，在常规治疗基础上静脉点滴奥扎格雷钠注射液80 mg，2次/天；静脉点滴小牛血去蛋白注射液800 mg，1次/天；同时，每晚口服阿司匹林片100 mg，1次/天，7 d为1疗程。实验组63例，在常规治疗的基础上加用盐酸小檗碱片0.7 g，口服，3次/天，7 d为1疗程。1个疗程结束后，分别观察急性脑梗死患者治疗前后血清中HIF-1α水平、血清中Caspase-3水平。结果治疗后2组血清中 HIF-1α水平均有所降低，但实验组血清中 HIF-1α水平（733.49±225.01）ng/mL 较对照组（975.32±311.35）ng/mL降低更加明显，差异有统计学意义（P＜0.05）。治疗后2组血清中Caspase-3水平均有所降低，但实验组血清中Caspase-3水平（11.88±2.66）ng/mL较对照组（12.51±3.77）ng/mL降低更加显著，差异有统计学意义（P＜0.05）。结论盐酸小檗碱可有效改善急性脑梗死患者血清中HIF-1α、Caspase-3水平，降低急性脑梗死患者病死率，可积极应用于急性脑梗死患者的恢复治疗。
目的：通過多中心研究，探究鹽痠小檗堿對急性腦梗死患者血清中HIF-1α、Caspase-3水平的影響。方法選取2012年1月～2014年1月河北工程大學附屬醫院、邯鄲市第一醫院、邯鄲市中心醫院神經內科收治的急性腦梗死患者共126例，採用隨機數字錶分為實驗組和對照組。對照組63例，在常規治療基礎上靜脈點滴奧扎格雷鈉註射液80 mg，2次/天；靜脈點滴小牛血去蛋白註射液800 mg，1次/天；同時，每晚口服阿司匹林片100 mg，1次/天，7 d為1療程。實驗組63例，在常規治療的基礎上加用鹽痠小檗堿片0.7 g，口服，3次/天，7 d為1療程。1箇療程結束後，分彆觀察急性腦梗死患者治療前後血清中HIF-1α水平、血清中Caspase-3水平。結果治療後2組血清中 HIF-1α水平均有所降低，但實驗組血清中 HIF-1α水平（733.49±225.01）ng/mL 較對照組（975.32±311.35）ng/mL降低更加明顯，差異有統計學意義（P＜0.05）。治療後2組血清中Caspase-3水平均有所降低，但實驗組血清中Caspase-3水平（11.88±2.66）ng/mL較對照組（12.51±3.77）ng/mL降低更加顯著，差異有統計學意義（P＜0.05）。結論鹽痠小檗堿可有效改善急性腦梗死患者血清中HIF-1α、Caspase-3水平，降低急性腦梗死患者病死率，可積極應用于急性腦梗死患者的恢複治療。
목적：통과다중심연구，탐구염산소벽감대급성뇌경사환자혈청중HIF-1α、Caspase-3수평적영향。방법선취2012년1월～2014년1월하북공정대학부속의원、함단시제일의원、함단시중심의원신경내과수치적급성뇌경사환자공126례，채용수궤수자표분위실험조화대조조。대조조63례，재상규치료기출상정맥점적오찰격뢰납주사액80 mg，2차/천；정맥점적소우혈거단백주사액800 mg，1차/천；동시，매만구복아사필림편100 mg，1차/천，7 d위1료정。실험조63례，재상규치료적기출상가용염산소벽감편0.7 g，구복，3차/천，7 d위1료정。1개료정결속후，분별관찰급성뇌경사환자치료전후혈청중HIF-1α수평、혈청중Caspase-3수평。결과치료후2조혈청중 HIF-1α수평균유소강저，단실험조혈청중 HIF-1α수평（733.49±225.01）ng/mL 교대조조（975.32±311.35）ng/mL강저경가명현，차이유통계학의의（P＜0.05）。치료후2조혈청중Caspase-3수평균유소강저，단실험조혈청중Caspase-3수평（11.88±2.66）ng/mL교대조조（12.51±3.77）ng/mL강저경가현저，차이유통계학의의（P＜0.05）。결론염산소벽감가유효개선급성뇌경사환자혈청중HIF-1α、Caspase-3수평，강저급성뇌경사환자병사솔，가적겁응용우급성뇌경사환자적회복치료。
Objective To explore the effect of berberine hydrochloride on serum HIF-1α,Caspase -3 levels in patients with acute cerebral infarction with a multicenter study.Methods 126 patients with acute cerebral infarction from January 2012 to January 2014 were selected in the Affiliated Hospital of Hebei Engineering University,the First Hospital of Handan City,Handan Central Hospital were divided into experimental groups and control group using random number table.Control group had 63 cases,were given 80 mg ozagrel sodium injection intravenously,twice a day,and 800 mg calf blood protein injection intravenously,once per day on the basis of conventional treatment;at the same time,100 mg of oral aspirin tablets were taken,once per night,7 days for a course of treatment.Experimental group were given berberine hydrochloride on the basis of conventional treatment,0.7 g orally,three times a day,7 days for a course of treatment.After a course of treatment,serum HIF-1α,Caspase-3 levels in patients with acute cerebral infarction were observed before and after treatment.Results Serum HIF-1αlevels in two groups were reduced after treatment,and its level in experimental group[(733.49 ±225.01)ng/mL]was lower than that in control group [(975.32 ±311.35)ng/mL],the difference was statistically significant (P<0.05 ).Serum Caspase-3 levels in two groups after treatment were decreased,and its level in experimental group [(1 1.88 ±2.66 )ng/mL]was lower than the control group [(12.51 ±3.77)ng/mL],the difference was statistically significant (P <0.05).Conclusion Berberine hydrochloride could improve the serum HIF-1α,Caspase-3 levels in patients with acute cerebral infarction,reduce the fatality rate,and could be actively used in the recovery of patients with acute cerebral infarction treatment.
