CAJ | 학술논문

目的：探讨茶多酚对维持性血液透析（maintenance hemodialysis，MHD）患者氧化应激和微炎症状态的影响及可能机制。方法60例MHD患者，随机分为常规组及茶多酚组；选择30个健康者作为正常对照组。3个月后检测常规组及茶多酚组丙二醛（malondialdehyde ，MDA）、晚期氧化蛋白产物（advanced oxidation protein products，AOPP）、超氧化物歧化酶（superoxide dismutase， SOD）、肿瘤坏死因子-α（turnor necrosis factor-α，TNF-α）、C-反应蛋白（C- reactive protein，CRP）、白介素-6（interleukin -6，IL-6）及核因子-κB（nuclear factor kappa B，NF-κB）。结果治疗前，常规组及茶多酚组与对照组相比MDA、AOPP升高（P＜0.01），SOD下降（P＜0.01）；治疗后，茶多酚组与常规组相比，MDA、AOPP下降（P＜0.01），SOD升高（P＜0.01）。治疗后，常规组及茶多酚组与对照组相比，NF-κB、TNF-α、CRP、IL-6、氧化指标均有所升高，存在统计学差异（P＜0.01）；茶多酚组与常规组相比，氧化指标均有所下降，存在统计学差异（p＜0.01）。结论茶多酚可以改善MHD患者的氧化应激和微炎症状态。
목적：탐토다다분대유지성혈액투석（maintenance hemodialysis，MHD）환자양화응격화미염증상태적영향급가능궤제。방법60례MHD환자，수궤분위상규조급다다분조；선택30개건강자작위정상대조조。3개월후검측상규조급다다분조병이철（malondialdehyde ，MDA）、만기양화단백산물（advanced oxidation protein products，AOPP）、초양화물기화매（superoxide dismutase， SOD）、종류배사인자-α（turnor necrosis factor-α，TNF-α）、C-반응단백（C- reactive protein，CRP）、백개소-6（interleukin -6，IL-6）급핵인자-κB（nuclear factor kappa B，NF-κB）。결과치료전，상규조급다다분조여대조조상비MDA、AOPP승고（P＜0.01），SOD하강（P＜0.01）；치료후，다다분조여상규조상비，MDA、AOPP하강（P＜0.01），SOD승고（P＜0.01）。치료후，상규조급다다분조여대조조상비，NF-κB、TNF-α、CRP、IL-6、양화지표균유소승고，존재통계학차이（P＜0.01）；다다분조여상규조상비，양화지표균유소하강，존재통계학차이（p＜0.01）。결론다다분가이개선MHD환자적양화응격화미염증상태。
Objective To investigate the influence and the possible mechanism of tea polyphenols on maintenance hemodialysis (MHD)patients’ oxidative stress and micro inflammatory condition.Methods 60 cases of MHD patients were randomly divided into routine group and tea polyphenols group.30 healthy subjects were chosen as normal control group.After 3 months,MDA,AOPP,SOD,TNF-α,CRP,IL-6 and NF-κB of routine group and tea polyphenols group were detected.Results Before treatment,compared with normal control group,MDA and AOPP of routine group and tea polyphenols group increased (P <0.01 ),SOD decreased (P <0.01 );after treatment,compared with routine group,MDA and AOPP of tea polyphenols group decreased (P<0.01),SOD increased (P<0.01).After treatment,compared with normal control group,NF-κB,TNF-α,CRP, IL-6 and oxidative index of routine group and tea polyphenols group increased,and the difference was statistically significant (P<0.01);compared with routine group,oxidative index of tea polyphenols group decreased,and the difference was statistically significant (P <0.01 ).Conclusion Tea polyphenol can improve MHD patients’oxidative stress and micro inflammatory state.