中国癌症杂志
中國癌癥雜誌
중국암증잡지
CHINA ONCOLOGY
2014年
10期
783-788
,共6页
赵宏%王琦%王昌华%赵守华
趙宏%王琦%王昌華%趙守華
조굉%왕기%왕창화%조수화
食管癌%活化T细胞核因子%转移
食管癌%活化T細胞覈因子%轉移
식관암%활화T세포핵인자%전이
Esophagueal neoplasm%Nuclear factor of activated T cells%Metastasis
背景与目的：研究发现，活化T细胞核因子(nuclear factor of activated T cells，NFAT)与多种恶性肿瘤关系密切，食管鳞癌是我国最常见的恶性肿瘤之一。本研究探讨食管鳞癌组织NFAT各亚型的表达及其与食管鳞癌各临床病理因素的关系。方法：采用免疫组化法检测104例食管鳞癌组织和癌旁食管黏膜组织中NFAT各亚型的表达情况。结果：NFAT1～4在食管鳞癌组织中阳性表达率分别为53.8%、10.6%、26.9%和45.2%，与在癌旁食管黏膜组织中的表达差异有统计学意义(P<0.001)。NFAT1的表达与饮酒史(62.3%vs 37.1%，P=0.01)、淋巴结转移(68.4%vs 5.5%，P=0.002)及较晚的分期(58.7%vs 36.2%，P=0.02)密切相关，多因素分析提示NFAT1过表达仅与淋巴结转移相关。淋巴结转移者的NFAT3表达率(39.4%)明显高于无淋巴结转移者(19.7%)。结论：NFAT蛋白在食管鳞癌组织中过表达，NFAT1与NFAT3的表达率与淋巴结转移密切相关，可能在肿瘤的发生、发展中起一定作用。
揹景與目的：研究髮現，活化T細胞覈因子(nuclear factor of activated T cells，NFAT)與多種噁性腫瘤關繫密切，食管鱗癌是我國最常見的噁性腫瘤之一。本研究探討食管鱗癌組織NFAT各亞型的錶達及其與食管鱗癌各臨床病理因素的關繫。方法：採用免疫組化法檢測104例食管鱗癌組織和癌徬食管黏膜組織中NFAT各亞型的錶達情況。結果：NFAT1～4在食管鱗癌組織中暘性錶達率分彆為53.8%、10.6%、26.9%和45.2%，與在癌徬食管黏膜組織中的錶達差異有統計學意義(P<0.001)。NFAT1的錶達與飲酒史(62.3%vs 37.1%，P=0.01)、淋巴結轉移(68.4%vs 5.5%，P=0.002)及較晚的分期(58.7%vs 36.2%，P=0.02)密切相關，多因素分析提示NFAT1過錶達僅與淋巴結轉移相關。淋巴結轉移者的NFAT3錶達率(39.4%)明顯高于無淋巴結轉移者(19.7%)。結論：NFAT蛋白在食管鱗癌組織中過錶達，NFAT1與NFAT3的錶達率與淋巴結轉移密切相關，可能在腫瘤的髮生、髮展中起一定作用。
배경여목적：연구발현，활화T세포핵인자(nuclear factor of activated T cells，NFAT)여다충악성종류관계밀절，식관린암시아국최상견적악성종류지일。본연구탐토식관린암조직NFAT각아형적표체급기여식관린암각림상병리인소적관계。방법：채용면역조화법검측104례식관린암조직화암방식관점막조직중NFAT각아형적표체정황。결과：NFAT1～4재식관린암조직중양성표체솔분별위53.8%、10.6%、26.9%화45.2%，여재암방식관점막조직중적표체차이유통계학의의(P<0.001)。NFAT1적표체여음주사(62.3%vs 37.1%，P=0.01)、림파결전이(68.4%vs 5.5%，P=0.002)급교만적분기(58.7%vs 36.2%，P=0.02)밀절상관，다인소분석제시NFAT1과표체부여림파결전이상관。림파결전이자적NFAT3표체솔(39.4%)명현고우무림파결전이자(19.7%)。결론：NFAT단백재식관린암조직중과표체，NFAT1여NFAT3적표체솔여림파결전이밀절상관，가능재종류적발생、발전중기일정작용。
Background and purpose:It was reported that nuclear factor of activated T cells (NFAT) is closely related with carcinomas. Esophageal squamous cell carcinoma (ESCC) is one of the most common carcinomas in China. The present study investigated the expression and clinical significance of NFAT isoforms in ESCC. Methods:The expression of NFAT isoforms and the differences in different pathological levels of ESCC were detected in 104 specimens of human ESCC tissues and normal esophageal tissues by immunohistochemistry. Results:This study found that the positive rates of NFAT1 (53.8%), NFAT2 (10.6%), NFAT3 (26.9%), NFAT4 (45.2%) expression were significantly higher in tumor tissues than in adjacent normal esophageal tissues (P<0.001), respectively. The positive rate of NFAT1 expression was significant-ly higher in drinkers (62.3%) than nondrinkers (37.1%, P=0.01), and also higher in patients with lymph node metastasis (68.4% vs 5.5%, P=0.002) and with late stage (58.7% vs 36.2%, P=0.02). Multivariate analysis showed that NFAT1 expression was correlated with lymph node metastasis. The positive rate of NFAT3 was significantly higher in patients with lymph node metastasis (39.4%) than in those without lymph node metastasis (19.7%, P=0.03). Conclusion:These results suggest that the overexpression of NFAT1 and NFAT3 is associated with lymph node metastasis in ESCC.
