中国癌症杂志
中國癌癥雜誌
중국암증잡지
CHINA ONCOLOGY
2014年
10期
721-726
,共6页
进展%淋巴瘤%B细胞%T和NK细胞%分类%侵袭性%惰性克隆性淋巴组织增生性疾病
進展%淋巴瘤%B細胞%T和NK細胞%分類%侵襲性%惰性剋隆性淋巴組織增生性疾病
진전%림파류%B세포%T화NK세포%분류%침습성%타성극륭성림파조직증생성질병
Advances%Lymphoma%B-cell%T and NK-cell%Classification%Aggressive%Indolent clonal lymphoproliferative disorders
2008年版WHO淋巴瘤分类出版以来的数年中，淋巴瘤病理相关的知识又有所更新。对于B细胞非霍奇金淋巴瘤，人们较关注那些高度侵袭而又异质的亚型(例如：弥漫性大B细胞淋巴瘤)，并努力尝试在分子生物学基础之上建立起更好的分型方法。此外，人们对于如何正确理解并处理明显的恶性淋巴瘤以及那些并不具有明确恶性行为、克隆性淋巴组织增生性疾病之间的“边界性”病变的兴趣也日益增长。另一方面，有关T和NK(T/NK)细胞的亚群构成、细胞分化方面的研究进展以及新近认识到的外周T/NK细胞淋巴瘤中的遗传学异常和信号路径调节失常，也有助于我们更深入地了解这些肿瘤的生物学特性。临床惰性、克隆性T/NK细胞增生性病变、特别是发生于黏膜皮肤部位者，也愈发受到人们关注。这些新的知识进展会推动淋巴瘤分类不断向前演进。
2008年版WHO淋巴瘤分類齣版以來的數年中，淋巴瘤病理相關的知識又有所更新。對于B細胞非霍奇金淋巴瘤，人們較關註那些高度侵襲而又異質的亞型(例如：瀰漫性大B細胞淋巴瘤)，併努力嘗試在分子生物學基礎之上建立起更好的分型方法。此外，人們對于如何正確理解併處理明顯的噁性淋巴瘤以及那些併不具有明確噁性行為、剋隆性淋巴組織增生性疾病之間的“邊界性”病變的興趣也日益增長。另一方麵，有關T和NK(T/NK)細胞的亞群構成、細胞分化方麵的研究進展以及新近認識到的外週T/NK細胞淋巴瘤中的遺傳學異常和信號路徑調節失常，也有助于我們更深入地瞭解這些腫瘤的生物學特性。臨床惰性、剋隆性T/NK細胞增生性病變、特彆是髮生于黏膜皮膚部位者，也愈髮受到人們關註。這些新的知識進展會推動淋巴瘤分類不斷嚮前縯進。
2008년판WHO림파류분류출판이래적수년중，림파류병리상관적지식우유소경신。대우B세포비곽기금림파류，인문교관주나사고도침습이우이질적아형(례여：미만성대B세포림파류)，병노력상시재분자생물학기출지상건립기경호적분형방법。차외，인문대우여하정학리해병처리명현적악성림파류이급나사병불구유명학악성행위、극륭성림파조직증생성질병지간적“변계성”병변적흥취야일익증장。령일방면，유관T화NK(T/NK)세포적아군구성、세포분화방면적연구진전이급신근인식도적외주T/NK세포림파류중적유전학이상화신호로경조절실상，야유조우아문경심입지료해저사종류적생물학특성。림상타성、극륭성T/NK세포증생성병변、특별시발생우점막피부부위자，야유발수도인문관주。저사신적지식진전회추동림파류분류불단향전연진。
Updated knowledge about lymphoma pathology has been accumulated ever since the publication of the current WHO classiifcation of lymphomas in 2008. For B-cell non-Hodgkin lymphomas, endeavors have been made for approaching a better classiifcation of those highly aggressive and heterogeneous subtypes (e.g., diffuse large B-cell lymphomas) on the molecular biological basis. In addition, there is a growing interest in understanding and deal-ing with the borders of overt malignant lymphomas and certain clonal lymphproliferative disorders that are not overtly malignant. On the other hand, recent advances in understanding the subsets of T and NK (T/NK)-cell lineage and their differentiation, as well as the genetic aberrations or dysregulated signaling pathways in their neoplastic counterparts, have provided us novel insights into the biology of peripheral T/NK-cell lymphomas. Indolent clonal T/NK-cell prolif-erations, especially those arising from the mucocutaneous sites, have also received increased attention. These advances may contribute to the evolution of the classiifcation of lymphomas.
