CAJ | 학술논문

目的：观察不同剂量胺碘酮治疗心律失常老年患者的疗效。方法120例老年心律失常患者随机分为 A、B、C 三组，分别采用高、中、低剂量的胺碘酮口服治疗，观察两组患者治疗前后心悸、胸闷等症状和动态心电图的变化，并监测三组患者用药后的血药浓度峰值。结果三组患者总有效率分别为82.5％、80.0％、80.0％，三组患者疗效对比差异无统计学意义(P>0.05)；用药后 A 组患者的血药浓度峰值明显高于 B 组和 C 组，且 B 组高于 C 组，差异均具有统计学意义(P<0.05)；A 组和 B 组起效时间明显短于 C 组，差异具有统计学意义(P<0.05)，但 A 组和 B 组差异无统计学意义(P>0.05)。结论口服胺碘酮要根据临床实际疗效，调整负荷量和维持量，以最小的维持量求得最好的疗效。
목적：관찰불동제량알전동치료심률실상노년환자적료효。방법120례노년심률실상환자수궤분위 A、B、C 삼조，분별채용고、중、저제량적알전동구복치료，관찰량조환자치료전후심계、흉민등증상화동태심전도적변화，병감측삼조환자용약후적혈약농도봉치。결과삼조환자총유효솔분별위82.5％、80.0％、80.0％，삼조환자료효대비차이무통계학의의(P>0.05)；용약후 A 조환자적혈약농도봉치명현고우 B 조화 C 조，차 B 조고우 C 조，차이균구유통계학의의(P<0.05)；A 조화 B 조기효시간명현단우 C 조，차이구유통계학의의(P<0.05)，단 A 조화 B 조차이무통계학의의(P>0.05)。결론구복알전동요근거림상실제료효，조정부하량화유지량，이최소적유지량구득최호적료효。
Objective To evaluate the clinical efficacy of various doses of amiodarone in the treatment of cardiac arrhythmia in elderly patients. Methods A total of 120 elderly patients with cardiac arrhythmia were randomly allocated to groups A, B, and C, and treated with high, medium, and low doses of oral amiodarone, respectively. The symptoms such as palpitation and chest distress were recorded, and the changes in dynamic electrocardiogram were measured in all groups before and after treatment. The maximum plasma concentration after medication was monitored in all groups. Results The overall response rates in the three groups were 82.5%, 80.0%, and 80.0%, respectively, and showed no significant difference between groups (P>0.05). After treatment, the maximum plasma concentration in group A was significantly higher than that in groups B and C; meanwhile, group B showed a significantly higher concentration than group C (all P<0.05). Groups A and B had a significantly faster onset of action than group C (P<0.05), but no significant difference was observed between groups A and B (P>0.05). conclusion The loading dose and maintaining dose of oral amiodarone should be adjusted following the therapeutic effect in order to achieve the best treatment outcome with a minimal maintaining dose.