CAJ | 학술논문

以2，6-二叔丁基苯酚（ DTBP）为原料通过亚硝化反应、还原反应合成2，6-二叔丁基-4-氨基苯酚（ DTBAP）。通过单因素实验系统考察了反应工艺条件得出：①亚硝化反应：以95%乙醇为溶剂，以浓盐酸为酸化试剂，亚硝酸钠用量为DTBP摩尔量1.25~1.50倍，反应温度为15~20℃，反应时间2.0~2.5 h，产品收率达90%以上；②还原反应：以连二亚硫酸钠为还原剂，在50~55℃下反应60 min，连二亚硫酸钠用量为2，6-二叔丁基-4-亚硝基苯酚摩尔数的2.8倍及以上，产品收率可达到92%以上。制备方法操作简单，反应条件温和、易于控制，产物易于分离，产品总收率较高，反应原料廉价、容易采购，生产成本较低，适合于工业化生产。
이2，6-이숙정기분분（ DTBP）위원료통과아초화반응、환원반응합성2，6-이숙정기-4-안기분분（ DTBAP）。통과단인소실험계통고찰료반응공예조건득출：①아초화반응：이95%을순위용제，이농염산위산화시제，아초산납용량위DTBP마이량1.25~1.50배，반응온도위15~20℃，반응시간2.0~2.5 h，산품수솔체90%이상；②환원반응：이련이아류산납위환원제，재50~55℃하반응60 min，련이아류산납용량위2，6-이숙정기-4-아초기분분마이수적2.8배급이상，산품수솔가체도92%이상。제비방법조작간단，반응조건온화、역우공제，산물역우분리，산품총수솔교고，반응원료렴개、용역채구，생산성본교저，괄합우공업화생산。
Using the 2,6-di-tert-butyl phenol( DTBP)as raw material,after the nitrosation reaetion and the reduetion reaetion,we eould get the di-tert-butyl-4-aminophenol( DTBAP). Through single faetors test effeets of reaetion eonditions,we eonsider the eondition of reaetion teehnology,and get the eonelusion:①the nitrosation reaetion:we ean get the produets at the rate up to 90% above,if we make 95% ethanol as the solvent,eoneentrated hydroehlorie aeid as aeidifieation reagents;the amount of the sodium nitrite is 1. 25~1. 50 times of the moles of the DTBP,the reaetion temperature 15~20 ℃;reaetion time is 2. 0~2 . 5 h;②the reduetion reaetion:we ean get the produets at the rate up to 92%,if we make the sodium di-thionite as the reduetant,the reaetion temperature 50~55 ℃;the amount of the sodium dithionite is more than 2. 8 times of the moles of 2,6-di-tert-butyl-4-nitrosophenol. The preparation method is simple,of a mild reaetion eonditions,easy to eontrol and easy to separate the produets,of high total yield,eheap and easy to get the raw materials,low produetion eosts. So it is suitable for industrial produetion.