中西医结合心脑血管病杂志
中西醫結閤心腦血管病雜誌
중서의결합심뇌혈관병잡지
CHINESE JOURNAL OF INTEGRATIVE MEDICINE ON CARDIO-/CEREBROVASCULAR DISEASE
2014年
11期
1316-1319
,共4页
冠状动脉疾病%尿酸%血管造影%代谢综合征
冠狀動脈疾病%尿痠%血管造影%代謝綜閤徵
관상동맥질병%뇨산%혈관조영%대사종합정
coronary artery disease%uric acid%coronary angiography%metabolic syndrome
目的:探讨血清尿酸(SUA)在疑似冠心病(CAD)患者中的临床价值。方法选取行冠脉造影检查者229例作为研究对象,根据冠脉病变支数分为无冠心病组和冠心病组,比较各组血清尿酸浓度和其他相关指标。结果161例患者有冠心病,冠心病组患者SUA浓度明显高于无冠心病组。SUA和冠心病严重程度显著相关。校正年龄、糖尿病、吸烟、血胆固醇和代谢综合征这些混杂因素后发现,SUA不是冠心病的独立危险因素。亚组分析表明,SUA和女性冠心病患者明显相关。与第一四分位数(<4.8mg/dL)相比,SUA在最高四分位数(≥6.4mg/dL)显示为CAD的风险增加(OR,1.88;95%CI,0.91~3.84),然而,这一结果的差异并不显著(P=0.075)。多元回归分析表明,代谢综合征(MS)是唯一的独立SUA水平决定因素,而前者和冠心病相关。结论血清尿酸不是冠心病的独立危险因素,而仅仅是胰岛素抵抗的一个标志。
目的:探討血清尿痠(SUA)在疑似冠心病(CAD)患者中的臨床價值。方法選取行冠脈造影檢查者229例作為研究對象,根據冠脈病變支數分為無冠心病組和冠心病組,比較各組血清尿痠濃度和其他相關指標。結果161例患者有冠心病,冠心病組患者SUA濃度明顯高于無冠心病組。SUA和冠心病嚴重程度顯著相關。校正年齡、糖尿病、吸煙、血膽固醇和代謝綜閤徵這些混雜因素後髮現,SUA不是冠心病的獨立危險因素。亞組分析錶明,SUA和女性冠心病患者明顯相關。與第一四分位數(<4.8mg/dL)相比,SUA在最高四分位數(≥6.4mg/dL)顯示為CAD的風險增加(OR,1.88;95%CI,0.91~3.84),然而,這一結果的差異併不顯著(P=0.075)。多元迴歸分析錶明,代謝綜閤徵(MS)是唯一的獨立SUA水平決定因素,而前者和冠心病相關。結論血清尿痠不是冠心病的獨立危險因素,而僅僅是胰島素牴抗的一箇標誌。
목적:탐토혈청뇨산(SUA)재의사관심병(CAD)환자중적림상개치。방법선취행관맥조영검사자229례작위연구대상,근거관맥병변지수분위무관심병조화관심병조,비교각조혈청뇨산농도화기타상관지표。결과161례환자유관심병,관심병조환자SUA농도명현고우무관심병조。SUA화관심병엄중정도현저상관。교정년령、당뇨병、흡연、혈담고순화대사종합정저사혼잡인소후발현,SUA불시관심병적독립위험인소。아조분석표명,SUA화녀성관심병환자명현상관。여제일사분위수(<4.8mg/dL)상비,SUA재최고사분위수(≥6.4mg/dL)현시위CAD적풍험증가(OR,1.88;95%CI,0.91~3.84),연이,저일결과적차이병불현저(P=0.075)。다원회귀분석표명,대사종합정(MS)시유일적독립SUA수평결정인소,이전자화관심병상관。결론혈청뇨산불시관심병적독립위험인소,이부부시이도소저항적일개표지。
O bjective To explo re the clinica l va lue o f serum uric acid (SUA) in pa tients w ith co ronary artery disease (CAD). M e thods There w ere 229 consecutive pa tients w ith suspected CAD w ho had undergone co ronary ang iog raphy. Pa tients w ere divid-ed into non CAD g roup o r CAD g roup acco rding to the results o f co ronary artery stenosis. The serum uric acid leve l and o ther pa-ram e ters w ere com pared be tw een tw o g roups. Results There w ere 161 pa tients w ith CAD. SUA w as higher in pa tients w ith CAD com pared w ith cases w ithoutCAD ( 5.5m g /dL± 1.0m g /dL vs. 5.2m g /dL± 1.0m g /dL, P = 0.004). SUA w as associa ted w ith signif-icantly severity o fCAD ( P = 0.002). After adjusting fo r significant confounding facto rs including age, diabe tes, sm oking, cho lestero l, and m e tabo lic syndrom e (M S), SUA w as no t an independent risk facto r o f CAD ( P = 0.151). Based on a subg roup ana lysis, SUA w as m o re close ly associa ted w ith CAD in w om en than in m en, and in the highest quartile ( ≥ 6.4m g /dL) than in the first quartile (<4.8 m g /dL). how ever,these results w ere no t significant( P = 0.062,P = 0.075,respective ly). In m ultivaria te reg ression ana lysis, the m ost im po rtant de term inant o f SUA w as M S, w hich w as strong ly associa ted w ith CAD. Conclusions In pa tients w ith suspected CAD, SUA is no t an independent risk facto r fo r CAD and itm ay be m ere ly a m arker o f insulin resistance.