中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2014年
11期
1595-1599
,共5页
郭涛%赵龙山%程佳%夏东亚%曾平%肖勇%赵东祥%李强%白音%杨长青
郭濤%趙龍山%程佳%夏東亞%曾平%肖勇%趙東祥%李彊%白音%楊長青
곽도%조룡산%정가%하동아%증평%초용%조동상%리강%백음%양장청
多沙普仑%药代动力学%高效液相色谱法%汉族%蒙古族%朝鲜族%维吾尔族%回族
多沙普崙%藥代動力學%高效液相色譜法%漢族%矇古族%朝鮮族%維吾爾族%迴族
다사보륜%약대동역학%고효액상색보법%한족%몽고족%조선족%유오이족%회족
doxapram%pharmacokinetics%HPLC%Chinese Han%Chinese Mongolian%Chinese Korean%Chinese Uigur%Chinese Hui
目的：考察单剂量静滴多沙普仑注射液在中国汉族、蒙古族、朝鲜族、维吾尔族和回族及不同性别健康受试者体内的药动学,为临床和战、创伤救治合理应用本品提供依据。方法健康汉、蒙、维、朝和回族受试者各10名,男女各半,禁食状态下单剂量静滴多沙普仑注射液50 mg,按设定的时间点采血,采用HPLC-UV法测定血浆中多沙普仑的浓度；通过DAS软件计算其药动学参数,采用SPSS软件对不同民族和性别的药动学参数进行统计分析。结果5个民族健康受试者单剂量静滴多沙普仑的药动学过程符合二室模型,汉、蒙、朝、回和维族健康受试者的药动学参数分别为：CL分别为(0．25±0．11)、(0．33±0．11)、(0．27±0．07)、(0．26±0．06)和(0．39±0．25) L·h-1·kg-1,Cmax分别为(1．55±0．52)、(1．02±0．30)、(1．31±0．47)、(1．48±0．46)和(0．99±0．35) mg·L-1。汉族受试者的AUC0-12．5、AUC0-∞和 Cmax明显高于维吾尔族和蒙古族(P<0．05),其他药动学参数五民族间差异无统计学意义( P>0．05)。男性与女性的Vc、Vd 和CL差异有统计学意义( P <0．05)。结论在战、创伤和平时临床应用本品时,应该对民族因素给予足够重视。
目的：攷察單劑量靜滴多沙普崙註射液在中國漢族、矇古族、朝鮮族、維吾爾族和迴族及不同性彆健康受試者體內的藥動學,為臨床和戰、創傷救治閤理應用本品提供依據。方法健康漢、矇、維、朝和迴族受試者各10名,男女各半,禁食狀態下單劑量靜滴多沙普崙註射液50 mg,按設定的時間點採血,採用HPLC-UV法測定血漿中多沙普崙的濃度；通過DAS軟件計算其藥動學參數,採用SPSS軟件對不同民族和性彆的藥動學參數進行統計分析。結果5箇民族健康受試者單劑量靜滴多沙普崙的藥動學過程符閤二室模型,漢、矇、朝、迴和維族健康受試者的藥動學參數分彆為：CL分彆為(0．25±0．11)、(0．33±0．11)、(0．27±0．07)、(0．26±0．06)和(0．39±0．25) L·h-1·kg-1,Cmax分彆為(1．55±0．52)、(1．02±0．30)、(1．31±0．47)、(1．48±0．46)和(0．99±0．35) mg·L-1。漢族受試者的AUC0-12．5、AUC0-∞和 Cmax明顯高于維吾爾族和矇古族(P<0．05),其他藥動學參數五民族間差異無統計學意義( P>0．05)。男性與女性的Vc、Vd 和CL差異有統計學意義( P <0．05)。結論在戰、創傷和平時臨床應用本品時,應該對民族因素給予足夠重視。
목적：고찰단제량정적다사보륜주사액재중국한족、몽고족、조선족、유오이족화회족급불동성별건강수시자체내적약동학,위림상화전、창상구치합리응용본품제공의거。방법건강한、몽、유、조화회족수시자각10명,남녀각반,금식상태하단제량정적다사보륜주사액50 mg,안설정적시간점채혈,채용HPLC-UV법측정혈장중다사보륜적농도；통과DAS연건계산기약동학삼수,채용SPSS연건대불동민족화성별적약동학삼수진행통계분석。결과5개민족건강수시자단제량정적다사보륜적약동학과정부합이실모형,한、몽、조、회화유족건강수시자적약동학삼수분별위：CL분별위(0．25±0．11)、(0．33±0．11)、(0．27±0．07)、(0．26±0．06)화(0．39±0．25) L·h-1·kg-1,Cmax분별위(1．55±0．52)、(1．02±0．30)、(1．31±0．47)、(1．48±0．46)화(0．99±0．35) mg·L-1。한족수시자적AUC0-12．5、AUC0-∞화 Cmax명현고우유오이족화몽고족(P<0．05),기타약동학삼수오민족간차이무통계학의의( P>0．05)。남성여녀성적Vc、Vd 화CL차이유통계학의의( P <0．05)。결론재전、창상화평시림상응용본품시,응해대민족인소급여족구중시。
Aim To investigate and compare the phar-macokinetics of doxapram injection in healthy subjects of different Chinese nationalities including Han, Mon-golian, Korean, Hui and Uigur, and the influence of gender,in order to provide instruction and help for the usage of doxapram for both clinic and remedy of battle wound. Methods An HPLC-UV method was used to determine the plasma concentration of doxapram. Fifty healthy subjects ( five males and five females of each nationality) were recruited for the study. A single dose of 50 mg doxapram was administered intravenously to the healthy subjects, and blood samples were collected at various predetermined time points. The pharmacoki-netic parameters were calculated by DAS software and were compared by SPSS 13. 0 software, in order to as-sess the influence of nationality or gender on pharmaco-kinetics of doxapram. Results The results indicated that the pharmacokinetic profile of doxapram in vivo could be described as two-compartment model. The main pharmacokinetic parameters for Han, Mongolian, Korean, Hui and Uygur were as follows: Cl ( 0. 25 ± 0. 11 ) , ( 0. 33 ± 0. 11 ) , ( 0. 27 ± 0. 07 ) , ( 0. 26 ± 0. 06) and (0. 39 ± 0. 25) L·h-1 ·kg-1 , while Cmax (1. 55 ± 0. 52 ) , ( 1. 02 ± 0. 30 ) , ( 1. 31 ± 0. 47 ) , (1. 48 ± 0. 46 ) and ( 0. 99 ± 0. 35 ) mg · L-1 . The AUC0-12. 5 , AUC0-∞ and Cmax of Chinese Han were sig-nificantly higher than those of Uigur and Mongolian ( P<0. 05 ) , while there was no significant difference in other parameters ( P>0. 05 ) . There were statistically significant differences in Vc , Vd and CL between young males and females ( P < 0. 05 ) . Conclusion The large inter-individual variation in the main pharmacoki-netics suggests the dosage of doxapram should be ad-justed for different nationalities for both clinic and rem-edy of battle wound.
